KCNH3

The protein encoded by this gene is a voltage-gated potassium channel alpha subunit predominantly expressed in the forebrain. Studies in mice have found that cognitive function increases when this gene is knocked out. In humans, the encoded protein has been shown to be capable of binding glycoprotein 120 of the human immunodeficiency virus type 1 (HIV-1) envelope. Two transcript variants encoding different isoforms have been found for this gene.

Full Name

potassium voltage-gated channel subfamily H member 3

Function

Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly.

Biological Process

Potassium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Potassium ion transportManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of ion transmembrane transportIEA:UniProtKB-KW
Regulation of membrane potentialManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Membrane

Topology

Cytoplasmic: 1-228
Helical: 229-249
Extracellular: 250-259
Helical: 260-280
Cytoplasmic: 281-302
Helical: 303-323
Extracellular: 324-331
Helical: 332-352
Cytoplasmic: 353-361
Helical: 362-382
Extracellular: 383-453
Pore-forming: 454-474
Extracellular: 475-479
Helical: 480-500
Cytoplasmic: 501-1083