Rabbit Anti-KCNH3 Recombinant Antibody (EG1756) (CBMAB-EN2095-LY)

Name: Rabbit Anti-KCNH3 Recombinant Antibody (EG1756)
SKU: CBMAB-EN2095-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

EG1756

Application

WB: 1:500~1:3000 ELISA: 1:40000

Immunogen

The antibody was produced against synthesized peptide derived from Internal of human KCNH3.

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

potassium voltage-gated channel subfamily H member 3

Introduction

The protein encoded by this gene is a voltage-gated potassium channel alpha subunit predominantly expressed in the forebrain. Studies in mice have found that cognitive function increases when this gene is knocked out. In humans, the encoded protein has been shown to be capable of binding glycoprotein 120 of the human immunodeficiency virus type 1 (HIV-1) envelope. Two transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

Human	23416
Mouse	16512
Rat	27150

UniProt ID

Human	Q9ULD8
Mouse	Q9WVJ0
Rat	O89047

Alternative Names

BEC1; ELK2; Kv12.2

Function

Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly.

Biological Process

Potassium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Potassium ion transportManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of ion transmembrane transportIEA:UniProtKB-KW
Regulation of membrane potentialManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Membrane

Topology

Cytoplasmic: 1-228
Helical: 229-249
Extracellular: 250-259
Helical: 260-280
Cytoplasmic: 281-302
Helical: 303-323
Extracellular: 324-331
Helical: 332-352
Cytoplasmic: 353-361
Helical: 362-382
Extracellular: 383-453
Pore-forming: 454-474
Extracellular: 475-479
Helical: 480-500
Cytoplasmic: 501-1083

Li, Z., Huang, L., Wei, L., Zhang, B., Zhong, S., Ou, Y., ... & Huang, S. (2020). KCNH3 predicts poor prognosis and promotes progression in ovarian cancer. OncoTargets and therapy, 10323-10333.

Takahashi, S., Okamura, A., Yamazaki, M., & Ni, K. (2020). ASP2905, a specific inhibitor of the potassium channel Kv12. 2 encoded by the Kcnh3 gene, is psychoactive in mice. Behavioural Brain Research, 378, 112315.

Takahashi, S., Ohmiya, M., Honda, S., & Ni, K. (2018). The KCNH3 inhibitor ASP2905 shows potential in the treatment of attention deficit/hyperactivity disorder. PLoS One, 13(11), e0207750.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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