KIF5B

Full Name

kinesin family member 5B

Function

Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity).
Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726).
Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity).
Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571).

Biological Process

Anterograde axonal protein transportISS:UniProtKB
Anterograde dendritic transport of neurotransmitter receptor complexManual Assertion Based On ExperimentIBA:GO_Central
Anterograde neuronal dense core vesicle transportISS:ARUK-UCL
Axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to interferon-gammaIEA:Ensembl
Centrosome localizationManual Assertion Based On ExperimentIMP:UniProtKB
Cytoplasm organizationIEA:Ensembl
Cytoskeleton-dependent intracellular transportManual Assertion Based On ExperimentIBA:GO_Central
Lysosome localizationManual Assertion Based On ExperimentIMP:UniProtKB
Microtubule-based movementManual Assertion Based On ExperimentIBA:GO_Central
Natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIMP:UniProtKB
Plus-end-directed vesicle transport along microtubuleIEA:Ensembl
Positive regulation of potassium ion transportManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of protein localization to plasma membraneManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of synaptic transmission, GABAergicIEA:Ensembl
Regulation of membrane potentialManual Assertion Based On ExperimentIDA:BHF-UCL
Retrograde neuronal dense core vesicle transportISS:ARUK-UCL
Stress granule disassemblyISS:BHF-UCL
Synaptic vesicle transportManual Assertion Based On ExperimentIBA:GO_Central
Vesicle transport along microtubuleManual Assertion Based On ExperimentIDA:ARUK-UCL

Cellular Location

Cytoplasm, cytoskeleton; Cytolytic granule membrane; Lysosome membrane. Uniformly distributed between soma and neurites in hippocampal neurons.