KIF5B
Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726).
Full Name
kinesin family member 5B
Function
Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity).
Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726).
Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity).
Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571).
Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726).
Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity).
Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571).
Biological Process
Anterograde axonal protein transportISS:UniProtKB
Anterograde dendritic transport of neurotransmitter receptor complexManual Assertion Based On ExperimentIBA:GO_Central
Anterograde neuronal dense core vesicle transportISS:ARUK-UCL
Axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to interferon-gammaIEA:Ensembl
Centrosome localizationManual Assertion Based On ExperimentIMP:UniProtKB
Cytoplasm organizationIEA:Ensembl
Cytoskeleton-dependent intracellular transportManual Assertion Based On ExperimentIBA:GO_Central
Lysosome localizationManual Assertion Based On ExperimentIMP:UniProtKB
Microtubule-based movementManual Assertion Based On ExperimentIBA:GO_Central
Natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIMP:UniProtKB
Plus-end-directed vesicle transport along microtubuleIEA:Ensembl
Positive regulation of potassium ion transportManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of protein localization to plasma membraneManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of synaptic transmission, GABAergicIEA:Ensembl
Regulation of membrane potentialManual Assertion Based On ExperimentIDA:BHF-UCL
Retrograde neuronal dense core vesicle transportISS:ARUK-UCL
Stress granule disassemblyISS:BHF-UCL
Synaptic vesicle transportManual Assertion Based On ExperimentIBA:GO_Central
Vesicle transport along microtubuleManual Assertion Based On ExperimentIDA:ARUK-UCL
Anterograde dendritic transport of neurotransmitter receptor complexManual Assertion Based On ExperimentIBA:GO_Central
Anterograde neuronal dense core vesicle transportISS:ARUK-UCL
Axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to interferon-gammaIEA:Ensembl
Centrosome localizationManual Assertion Based On ExperimentIMP:UniProtKB
Cytoplasm organizationIEA:Ensembl
Cytoskeleton-dependent intracellular transportManual Assertion Based On ExperimentIBA:GO_Central
Lysosome localizationManual Assertion Based On ExperimentIMP:UniProtKB
Microtubule-based movementManual Assertion Based On ExperimentIBA:GO_Central
Natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIMP:UniProtKB
Plus-end-directed vesicle transport along microtubuleIEA:Ensembl
Positive regulation of potassium ion transportManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of protein localization to plasma membraneManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of synaptic transmission, GABAergicIEA:Ensembl
Regulation of membrane potentialManual Assertion Based On ExperimentIDA:BHF-UCL
Retrograde neuronal dense core vesicle transportISS:ARUK-UCL
Stress granule disassemblyISS:BHF-UCL
Synaptic vesicle transportManual Assertion Based On ExperimentIBA:GO_Central
Vesicle transport along microtubuleManual Assertion Based On ExperimentIDA:ARUK-UCL
Cellular Location
Cytoplasm, cytoskeleton; Cytolytic granule membrane; Lysosome membrane. Uniformly distributed between soma and neurites in hippocampal neurons.
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Anti-KIF5B antibodies
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CompareTarget: KIF5B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2A11
Application*: E, WB
Target: KIF5B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBLY1-088
Application*: WB, IP, P, IC/IF
Target: KIF5B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLY1-089
Application*: WB, P, F, IC/IF
Target: KIF5B
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: KIF5B (1-575) - RET (713-end 804)
Tag: GST Tag
Target: KIF5B
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: KIF5B (1-575) - RET (713-end 804)
Tag: GST Tag
Target: KIF5B
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: KIF5B (1-575)-RET (713-end)
Tag: GST Tag
Target: KIF5B
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: KIF5B (1-921)-(963-end)
Tag: GST Tag
Target: KIF5B
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: KIF5B (1-921)-ALK (1058-end)
Tag: GST Tag
Target: KIF5B
Host: Mouse
Antibody Isotype: IgM
Specificity: Pig, Human, Mouse, Rat
Clone: KN-02
Application*: IC/IF
Target: KIF5B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Cattle
Clone: L2
Application*: E, WB
Target: KIF5B
Host: Mouse
Antibody Isotype: IgM
Specificity: Pig, Human, Mouse, Rat
Clone: KN-03
Application*: IC
Target: KIF5B
Host: Mouse
Antibody Isotype: IgM
Specificity: Pig, Human, Mouse
Clone: KN-01
Application*: E, IA, IF
Target: KIF5B
Host: Mouse
Antibody Isotype: IgM
Specificity: Cattle, Rat
Clone: IBII
Application*: WB, E
Target: KIF5B
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Cattle
Clone: H2
Application*: E, C, P, IP, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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