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KIF5B

Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726).
Full Name
kinesin family member 5B
Function
Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity).
Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726).
Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity).
Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571).
Biological Process
Anterograde axonal protein transportISS:UniProtKB
Anterograde dendritic transport of neurotransmitter receptor complexManual Assertion Based On ExperimentIBA:GO_Central
Anterograde neuronal dense core vesicle transportISS:ARUK-UCL
Axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to interferon-gammaIEA:Ensembl
Centrosome localizationManual Assertion Based On ExperimentIMP:UniProtKB
Cytoplasm organizationIEA:Ensembl
Cytoskeleton-dependent intracellular transportManual Assertion Based On ExperimentIBA:GO_Central
Lysosome localizationManual Assertion Based On ExperimentIMP:UniProtKB
Microtubule-based movementManual Assertion Based On ExperimentIBA:GO_Central
Natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIMP:UniProtKB
Plus-end-directed vesicle transport along microtubuleIEA:Ensembl
Positive regulation of potassium ion transportManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of protein localization to plasma membraneManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of synaptic transmission, GABAergicIEA:Ensembl
Regulation of membrane potentialManual Assertion Based On ExperimentIDA:BHF-UCL
Retrograde neuronal dense core vesicle transportISS:ARUK-UCL
Stress granule disassemblyISS:BHF-UCL
Synaptic vesicle transportManual Assertion Based On ExperimentIBA:GO_Central
Vesicle transport along microtubuleManual Assertion Based On ExperimentIDA:ARUK-UCL
Cellular Location
Cytoplasm, cytoskeleton; Cytolytic granule membrane; Lysosome membrane. Uniformly distributed between soma and neurites in hippocampal neurons.

Anti-KIF5B antibodies

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Target: KIF5B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLY1-089
Application*: WB, P, F, IC/IF
Target: KIF5B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2A11
Application*: E, WB
Target: KIF5B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBLY1-088
Application*: WB, IP, P, IC/IF
Target: KIF5B
Host: Mouse
Antibody Isotype: IgM
Specificity: Cattle, Rat
Clone: IBII
Application*: WB, E
Target: KIF5B
Host: Mouse
Antibody Isotype: IgM
Specificity: Pig, Human, Mouse
Clone: KN-01
Application*: E, IA, IF
Target: KIF5B
Host: Mouse
Antibody Isotype: IgM
Specificity: Pig, Human, Mouse, Rat
Clone: KN-03
Application*: IC
Target: KIF5B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Cattle
Clone: L2
Application*: E, WB
Target: KIF5B
Host: Mouse
Antibody Isotype: IgM
Specificity: Pig, Human, Mouse, Rat
Clone: KN-02
Application*: IC/IF
Target: KIF5B
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Cattle
Clone: H2
Application*: E, C, P, IP, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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