KLF7

The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants.

Full Name

Kruppel like factor 7

Function

Transcriptional factor (PubMed:9774444, PubMed:16339272).
Plays a critical role in neuronal morphogenesis and survival of sensory neurons (By similarity).
Represses the corneal epithelium differentiation (PubMed:28916725).
Acts also as a metabolic regulator, by modulating insulin sensitivity in pancreatic beta cells and skeletal muscle cells (PubMed:16339272).
Inhibits transcriptional inducers of adipogenesis and has a repressive role in the expression of several adipokines, including leptin (PubMed:16339272).

Biological Process

Axon guidanceISS:UniProtKB
AxonogenesisISS:UniProtKB
Dendrite morphogenesisISS:UniProtKB
Glucose homeostasisManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of adipose tissue developmentManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of insulin secretion involved in cellular response to glucose stimulusManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Regulation of epidermal cell differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus