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Mouse Anti-KLF7 Monoclonal Antibody (AT3G3) (CBMAB-1371-YC)

Provided herein is a mouse monoclonal antibody against Human KLF7 . The antibody, clone AT3G3, can be used for immunoassay techniques, such as WB.
See all KLF7 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
AT3G3
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Recombinant full length protein corresponding to Human KLF7 aa 1-302. purified from E. coli (NP_003700)
Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Kruppel like factor 7
Introduction
KLF7 is a member of the Kruppel-like transcriptional regulator family. KLF7 may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes.
Entrez Gene ID
Human8609
Mouse93691
UniProt ID
HumanO75840
MouseQ99JB0
Alternative Names
UKLF
Function
Transcriptional factor (PubMed:9774444, PubMed:16339272).
Plays a critical role in neuronal morphogenesis and survival of sensory neurons (By similarity).
Represses the corneal epithelium differentiation (PubMed:28916725).
Acts also as a metabolic regulator, by modulating insulin sensitivity in pancreatic beta cells and skeletal muscle cells (PubMed:16339272).
Inhibits transcriptional inducers of adipogenesis and has a repressive role in the expression of several adipokines, including leptin (PubMed:16339272).
Biological Process
Axon guidanceISS:UniProtKB
AxonogenesisISS:UniProtKB
Dendrite morphogenesisISS:UniProtKB
Glucose homeostasisManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of adipose tissue developmentManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of insulin secretion involved in cellular response to glucose stimulusManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Regulation of epidermal cell differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus

Mao, Y., Chen, Y., & Zhang, Z. (2023). Molecular function of Krüppel-like factor 7 in biology: Molecular function of KLF7 in biology. Acta Biochimica et Biophysica Sinica, 55(5), 713.

Chen, C., Hu, F., Miao, S., Sun, L., Jiao, Y., Xu, M., ... & Zhou, R. (2022). Transcription factor KLF7 promotes osteoclast differentiation by suppressing HO-1. Frontiers in Genetics, 13, 798433.

Lyu, J., Wang, J., Miao, Y., Xu, T., Zhao, W., Bao, T., & Zhu, H. (2022). KLF7 is associated with poor prognosis and regulates migration and adhesion in tongue cancer. Oral Diseases, 28(3), 577-584.

Huang, W. H., Xue, Y. J., Zhou, Y. J., Wu, X. G., Wu, X. X., Zhang, X. X., ... & Wei, Y. T. (2020). KLF7 promotes macrophage activation by activating the NF-κB signaling pathway in epicardial adipose tissue in patients with coronary artery disease. European Review for Medical & Pharmacological Sciences, 24(12).

Niu, R., Tang, Y., Xi, Y., & Jiang, D. (2020). High expression of Krüppel-like factor 7 indicates unfavorable clinical outcomes in patients with lung adenocarcinoma. Journal of Surgical Research, 250, 216-223.

Yang, J., Xie, K., Wang, Z., & Li, C. (2020). Elevated KLF7 levels may serve as a prognostic signature and might contribute to progression of squamous carcinoma. FEBS Open Bio, 10(8), 1577-1586.

Gupta, R., Malvi, P., Parajuli, K. R., Janostiak, R., Bugide, S., Cai, G., ... & Wajapeyee, N. (2020). KLF7 promotes pancreatic cancer growth and metastasis by up-regulating ISG expression and maintaining Golgi complex integrity. Proceedings of the National Academy of Sciences, 117(22), 12341-12351.

Guan, F., Kang, Z., Zhang, J. T., Xue, N. N., Yin, H., Wang, L., ... & Hu, Z. Q. (2019). KLF7 promotes polyamine biosynthesis and glioma development through transcriptionally activating ASL. Biochemical and biophysical research communications, 514(1), 51-57.

Zhang, M., Wang, C., Wu, J., Ha, X., Deng, Y., Zhang, X., ... & Zhang, J. (2018). The effect and mechanism of KLF7 in the TLR4/NF-κB/IL-6 inflammatory signal pathway of adipocytes. Mediators of Inflammation, 2018.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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