KNTC1

This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. Experimental evidence indicated that the encoded protein functioned in a similar manner to that of the Drosophila rough deal protein. [provided by RefSeq]

Full Name

kinetochore associated 1

Function

Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores (PubMed:11146660, PubMed:11590237, PubMed:15824131).
Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex.

Biological Process

Cell divisionIEA:UniProtKB-KW
Mitotic sister chromatid segregationManual Assertion Based On ExperimentIBA:GO_Central
Mitotic spindle assembly checkpoint signalingManual Assertion Based On ExperimentIDA:UniProtKB
Protein localization to kinetochore involved in kinetochore assemblyManual Assertion Based On ExperimentIBA:GO_Central
Protein-containing complex assembly1 PublicationNAS:UniProtKB
Regulation of exit from mitosis1 PublicationNAS:UniProtKB

Cellular Location

Cytoplasm
Nucleus
Chromosome, centromere, kinetochore
Cytoplasm, cytoskeleton, spindle
Dynamic pattern of localization during the cell cycle. At interphase, uniformly distributed throughout the cytoplasm and nucleus. By prophase and until late stages of prometaphase, a fraction of the total pool is concentrated at kinetochores. By metaphase, detected at kinetochores, along spindle fibers and most prominently at the poles. By late anaphase until the end of telophase, no longer detectable on kinetochores or along spindle fibers, but still present at the spindle poles.