KRT12

KRT12 encodes the type I intermediate filament chain keratin 12, expressed in corneal epithelia. Mutations in this gene lead to Meesmann corneal dystrophy. [provided by RefSeq, Jul 2008]
Full Name
Keratin 12
Function
Involved in corneal epithelium organization, integrity and corneal keratin expression.
Biological Process
Cornea development in camera-type eyeManual Assertion Based On ExperimentIMP:UniProtKB
Morphogenesis of an epitheliumManual Assertion Based On ExperimentIMP:UniProtKB
Visual perceptionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytosol
Extracellular exosome
Intermediate filament
Involvement in disease
Corneal dystrophy, Meesmann 1 (MECD1):
A form of Meesmann corneal dystrophy, a corneal disease characterized by fragility of the anterior corneal epithelium. Histological examination shows a disorganized and thickened epithelium with widespread cytoplasmic vacuolation and numerous small, round, debris-laden intraepithelial cysts. Patients are usually asymptomatic until adulthood when rupture of the corneal microcysts may cause erosions, producing clinical symptoms such as photophobia, contact lens intolerance and intermittent diminution of visual acuity. Rarely, subepithelial scarring causes irregular corneal astigmatism and permanent visual impairment. MECD1 inheritance is autosomal dominant.
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Anti-KRT12 antibodies

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Rabbit Anti-KRT12 Recombinant Antibody (CBLY1-144) (CBMAB-K1594-LY)

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Target: KRT12
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBLY1-144
Application*: WB, P, IC/IF
Datasheet SDS

Rabbit Anti-KRT12 Recombinant Antibody (CBLY1-143) (CBMAB-K1593-LY)

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Target: KRT12
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat, Human
Clone: CBLY1-143
Application*: WB
Datasheet SDS

Rabbit Anti-KRT12 Recombinant Antibody (BA0170) (CBMAB-0439CQ)

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Target: KRT12
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: BA0170
Application*: P, WB
Datasheet SDS

Rabbit Anti-KRT12 Recombinant Antibody (BA0169) (CBMAB-0438CQ)

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Target: KRT12
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: BA0169
Application*: IF, P, WB
Datasheet SDS
More Infomation
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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