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Rabbit Anti-KRT12 Recombinant Antibody (BA0169) (CBMAB-0438CQ)

This product is a rabbit antibody that recognizes KRT12. The antibody BA0169 can be used for immunoassay techniques such as: IF, IHC-P, WB.
See all KRT12 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
BA0169
Antibody Isotype
IgG
Application
IF, IHC-P, WB

Basic Information

Immunogen
Human Keratin 12 aa 250 to the C-terminus
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Keratin 12
Introduction
KRT12 encodes the type I intermediate filament chain keratin 12, expressed in corneal epithelia. Mutations in this gene lead to Meesmann corneal dystrophy. Kao et al. (1996) stated that the corneal-specific nature of keratin-12 gene expression signifies keratin-12 plays a unique role in maintaining normal corneal epithelial function. Nishida et al. (1997) presented the exon-intron boundary structure of the KRT12 gene. The gene contains 8 exons and spans approximately 6 kb of genomic DNA.
Entrez Gene ID
Human3859
Mouse268482
Rat360625
UniProt ID
HumanQ99456
MouseQ64291
RatQ6IFW5
Alternative Names
K12
Function
Involved in corneal epithelium organization, integrity and corneal keratin expression.
Biological Process
Cornea development in camera-type eyeManual Assertion Based On ExperimentIMP:UniProtKB
Morphogenesis of an epitheliumManual Assertion Based On ExperimentIMP:UniProtKB
Visual perceptionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytosol
Extracellular exosome
Intermediate filament
Involvement in disease
Corneal dystrophy, Meesmann 1 (MECD1):
A form of Meesmann corneal dystrophy, a corneal disease characterized by fragility of the anterior corneal epithelium. Histological examination shows a disorganized and thickened epithelium with widespread cytoplasmic vacuolation and numerous small, round, debris-laden intraepithelial cysts. Patients are usually asymptomatic until adulthood when rupture of the corneal microcysts may cause erosions, producing clinical symptoms such as photophobia, contact lens intolerance and intermittent diminution of visual acuity. Rarely, subepithelial scarring causes irregular corneal astigmatism and permanent visual impairment. MECD1 inheritance is autosomal dominant.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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