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Rabbit Anti-KRT12 Recombinant Antibody (CBLY1-143) (CBMAB-K1593-LY)

This product is antibody recognizes KRT12. The antibody CBLY1-143 immunoassay techniques such as: WB.
See all KRT12 antibodies

Summary

Host Animal
Rabbit
Specificity
Rat, Human
Clone
CBLY1-143
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Keratin 12
Introduction
KRT12 encodes the type I intermediate filament chain keratin 12, expressed in corneal epithelia. Mutations in this gene lead to Meesmann corneal dystrophy. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human3859
Rat360625
UniProt ID
HumanQ99456
RatQ6IFW5
Function
Involved in corneal epithelium organization, integrity and corneal keratin expression.
Biological Process
Cornea development in camera-type eyeManual Assertion Based On ExperimentIMP:UniProtKB
Morphogenesis of an epitheliumManual Assertion Based On ExperimentIMP:UniProtKB
Visual perceptionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytosol
Extracellular exosome
Intermediate filament
Involvement in disease
Corneal dystrophy, Meesmann 1 (MECD1):
A form of Meesmann corneal dystrophy, a corneal disease characterized by fragility of the anterior corneal epithelium. Histological examination shows a disorganized and thickened epithelium with widespread cytoplasmic vacuolation and numerous small, round, debris-laden intraepithelial cysts. Patients are usually asymptomatic until adulthood when rupture of the corneal microcysts may cause erosions, producing clinical symptoms such as photophobia, contact lens intolerance and intermittent diminution of visual acuity. Rarely, subepithelial scarring causes irregular corneal astigmatism and permanent visual impairment. MECD1 inheritance is autosomal dominant.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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