KRT3

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the corneal epithelium with family member KRT12 and mutations in these genes have been associated with Meesmann's Corneal Dystrophy. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
Full Name
Keratin 3
Biological Process
Epithelial cell differentiationISS:UniProtKB
Intermediate filament cytoskeleton organizationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytosol
Extracellular exosome
Intermediate filament
Keratin filament
Involvement in disease
Corneal dystrophy, Meesmann 2 (MECD2):
A form of Meesmann corneal dystrophy, a corneal disease characterized by fragility of the anterior corneal epithelium. Histological examination shows a disorganized and thickened epithelium with widespread cytoplasmic vacuolation and numerous small, round, debris-laden intraepithelial cysts. Patients are usually asymptomatic until adulthood when rupture of the corneal microcysts may cause erosions, producing clinical symptoms such as photophobia, contact lens intolerance and intermittent diminution of visual acuity. Rarely, subepithelial scarring causes irregular corneal astigmatism and permanent visual impairment. MECD2 inheritance is autosomal dominant.
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Anti-KRT3 antibodies

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Mouse Anti-KRT3 Recombinant Antibody (CBCNC-640) (CBMAB-C3851-CN)

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Target: KRT3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Frog
Clone: CBCNC-640
Application*: P, IF
Datasheet SDS

Mouse Anti-KRT3 Recombinant Antibody (2Q1040) (CBMAB-C5324-LY)

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Target: KRT3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Dog, Rabbit
Clone: 2Q1040
Application*: WB, P, C
Datasheet SDS

Mouse Anti-KRT3 Recombinant Antibody (AE5) (CBMAB-K1871-LY)

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Target: KRT3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Cattle, Rabbit
Clone: AE5
Application*: C, WB
Datasheet SDS

Mouse Anti-KRT3 Recombinant Antibody (CBWJC-4051) (CBMAB-C5380WJ)

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Target: KRT3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat, Rabbit, Chicken, Cattle, Human, Pig, Monkey
Clone: CBWJC-4051
Application*: P, C, IC
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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