Sign in or Register   Sign in or Register
  |  

Mouse Anti-KRT3 Recombinant Antibody (CBWJC-4051) (CBMAB-C5380WJ)

This product is a Mouse antibody that recognizes KRT3. This antibody CBWJC-4051 can be used for immunoassay techniques such as: IHC-P, IHC-Fr, ICC.
See all KRT3 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Rabbit, Chicken, Cattle, Human, Pig, Monkey
Clone
CBWJC-4051
Antibody Isotype
IgG1
Application
IHC-P, IHC-Fr, ICC

Basic Information

Specificity
Mouse, Rat, Rabbit, Chicken, Cattle, Human, Pig, Monkey
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
0.2 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Keratin 3
Introduction
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the corneal epithelium with family member KRT12 and mutations in these genes have been associated with Meesmann's Corneal Dystrophy. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human3850
Cattle407188
Rabbit100353668
Chicken112529931
Pig100157304
Monkey100425096
UniProt ID
HumanP12035
CattleG3MXL3
RabbitQ29426
PigI3LDM6
MonkeyA0A2K5U8Y5
Alternative Names
Keratin 3; Keratin, Type II Cytoskeletal 3; Type-II Keratin Kb3; 5 KDa Cytokeratin; Cytokeratin 3; CK-3;
Biological Process
Epithelial cell differentiationISS:UniProtKB
Intermediate filament cytoskeleton organizationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytosol
Extracellular exosome
Intermediate filament
Keratin filament
Involvement in disease
Corneal dystrophy, Meesmann 2 (MECD2):
A form of Meesmann corneal dystrophy, a corneal disease characterized by fragility of the anterior corneal epithelium. Histological examination shows a disorganized and thickened epithelium with widespread cytoplasmic vacuolation and numerous small, round, debris-laden intraepithelial cysts. Patients are usually asymptomatic until adulthood when rupture of the corneal microcysts may cause erosions, producing clinical symptoms such as photophobia, contact lens intolerance and intermittent diminution of visual acuity. Rarely, subepithelial scarring causes irregular corneal astigmatism and permanent visual impairment. MECD2 inheritance is autosomal dominant.

Takan, I., Karakülah, G., Louka, A., & Pavlopoulou, A. (2023). “In the light of evolution:” keratins as exceptional tumor biomarkers. PeerJ, 11, e15099.

Ho, M., Thompson, B., Fisk, J. N., Nebert, D. W., Bruford, E. A., Vasiliou, V., & Bunick, C. G. (2022). Update of the keratin gene family: evolution, tissue-specific expression patterns, and relevance to clinical disorders. Human Genomics, 16(1), 1-21.

Li, C., Shi, Y., Zuo, L., Xin, M., Guo, X., Sun, J., ... & Zhao, H. (2022). Identification of biomarkers associated with cancerous change in oral leukoplakia based on integrated transcriptome analysis. Journal of Oncology, 2022.

Abad-Morales, V., Barbany, M., Gris, O., Güell, J. L., & Pomares, E. (2021). Coexistence of meesmann corneal dystrophy and a pseudo-unilateral lattice corneal dystrophy in a patient with a novel pathogenic variant in the keratin K3 gene: a case report. Cornea, 40(3), 370.

Latta, L., Knebel, I., Bleil, C., Stachon, T., Katiyar, P., Zussy, C., ... & Szentmáry, N. (2021). Similarities in DSG1 and KRT3 Downregulation through Retinoic Acid Treatment and PAX6 Knockdown Related Expression Profiles: Does PAX6 Affect RA Signaling in Limbal Epithelial Cells?. Biomolecules, 11(11), 1651.

Dong, P. N., Cung, L. X., Sam, T. K., Hang, D. T. T., Chung, D. D., Alkadi, T. A., ... & Aldave, A. J. (2020). Identification of a novel missense KRT12 mutation in a Vietnamese family with Meesmann corneal dystrophy. Case Reports in Ophthalmology, 11(1), 120-126.

da Mata Martins, T. M., da Silva Cunha, P., Rodrigues, M. A., de Carvalho, J. L., de Souza, J. E., de Carvalho Oliveira, J. A., ... & de Goes, A. M. (2020). Epithelial basement membrane of human decellularized cornea as a suitable substrate for differentiation of embryonic stem cells into corneal epithelial-like cells. Materials Science and Engineering: C, 116, 111215.

Nishino, T., Kobayashi, A., Mori, N., Masaki, T., Yokogawa, H., Fujiki, K., ... & Sugiyama, K. (2019). In vivo histology and p. L132V mutation in KRT12 gene in Japanese patients with Meesmann corneal dystrophy. Japanese Journal of Ophthalmology, 63, 46-55.

Ehrlich, F., Laggner, M., Langbein, L., Burger, P., Pollreisz, A., Tschachler, E., & Eckhart, L. (2019). Comparative genomics suggests loss of keratin K24 in three evolutionary lineages of mammals. Scientific reports, 9(1), 10924.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-KRT3 Recombinant Antibody (CBWJC-4051)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare