LAMA5

Components of the extracellular matrix exert myriad effects on tissues throughout the body. In particular, the laminins, a family of heterotrimeric extracellular glycoproteins, affect tissue development and integrity in such diverse organs as the kidney, lung, skin, and nervous system. It is thought that laminins mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminins function as heterotrimeric complexes of alpha, beta, and gamma chains, with each chain type representing a different subfamily of proteins. The protein encoded by this gene belongs to the alpha subfamily of laminin chains and is a major component of basement membranes. Two transcript variants encoding different isoforms have been found for this gene, but the full-length nature of one of them has not been determined. [provided by RefSeq]

Full Name

laminin, alpha 5

Function

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

Biological Process

Animal organ morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Branching involved in salivary gland morphogenesisIEA:Ensembl
Branching involved in ureteric bud morphogenesisIEA:Ensembl
Cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Cell-cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Cilium assemblyIEA:Ensembl
Hair follicle developmentIEA:Ensembl
Integrin-mediated signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Lung developmentIEA:Ensembl
Morphogenesis of a polarized epitheliumManual Assertion Based On ExperimentIBA:GO_Central
Morphogenesis of embryonic epitheliumIEA:Ensembl
Muscle organ developmentIEA:Ensembl
Neural crest cell migrationIEA:Ensembl
Odontogenesis of dentin-containing toothIEA:Ensembl
Protein localization to plasma membraneIEA:Ensembl
Regulation of cell adhesionIEA:InterPro
Regulation of cell migrationIEA:InterPro
Regulation of cell population proliferationIEA:Ensembl
Regulation of embryonic developmentIEA:InterPro
Substrate adhesion-dependent cell spreadingManual Assertion Based On ExperimentIDA:BHF-UCL
Tissue developmentManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Secreted, extracellular space, extracellular matrix, basement membrane
Major component.