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LAMB2

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Diseases associated with LAMB2 include Pierson Syndrome and Nephrotic Syndrome, Type 5, With Or Without Ocular Abnormalities. Among its related pathways are ECM proteoglycans and miRNA targets in ECM and membrane receptors.
Full Name
LAMB2
Function
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Biological Process
Animal organ morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Astrocyte developmentIEA:Ensembl
Axon extension involved in regenerationIEA:Ensembl
Axon guidanceIEA:Ensembl
Basement membrane assemblyManual Assertion Based On ExperimentIBA:GO_Central
Cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Metanephric glomerular basement membrane developmentIEA:Ensembl
Metanephric glomerular visceral epithelial cell developmentIEA:Ensembl
Neuromuscular junction developmentIEA:Ensembl
Retina development in camera-type eyeIEA:Ensembl
Schwann cell developmentIEA:Ensembl
Substrate adhesion-dependent cell spreadingManual Assertion Based On ExperimentIBA:GO_Central
Tissue developmentManual Assertion Based On ExperimentIBA:GO_Central
Visual perceptionIEA:Ensembl
Cellular Location
Secreted, extracellular space, extracellular matrix, basement membrane
S-laminin is concentrated in the synaptic cleft of the neuromuscular junction.
Involvement in disease
Pierson syndrome (PIERSS):
Characterized by nephrotic syndrome with neonatal onset, diffuse mesangial sclerosis and eye abnormalities with microcoria as the leading clinical feature. Death usually occurs within the first weeks of life. Disease severity depends on the mutation type: nontruncating LAMB2 mutations may display variable phenotypes ranging from a milder variant of Pierson syndrome to isolated congenital nephrotic syndrome.
Nephrotic syndrome 5 with or without ocular abnormalities (NPHS5):
A form of nephrotic syndrome, a renal disease clinically characterized by severe proteinuria, resulting in complications such as hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form and progress to end-stage renal failure. NPHS5 is characterized by very early onset of progressive renal failure. A subset of patients may develop mild ocular anomalies, such as myopia, nystagmus, and strabismus.

Anti-LAMB2 antibodies

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Target: LAMB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Dog, Chicken, Guinea pig, Human, Rabbit, Rat
Clone: C4
Application*: B, IF, IP, WB
Target: LAMB2
Host: Rat
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBYJL-1120
Application*: P, C
Target: LAMB2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: D18
Application*: P
Target: LAMB2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Rat
Clone: CBYJL-1118
Application*: WB, P
Target: LAMB2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJL-1116
Application*: WB, P
Target: LAMB2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJL-1115
Application*: WB, P
Target: LAMB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1114
Application*: WB, P
Target: LAMB2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJL-1113
Application*: C, P
Target: LAMB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3B4
Application*: WB, IH
Target: LAMB2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJL-1112
Application*: E, WB
Target: LAMB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rabbit, Rat
Clone: CBYJL-1111
Application*: WB, BI
Target: LAMB2
Host: Rat
Antibody Isotype: IgG2, κ
Specificity: Human, Mouse
Clone: CBYJL-1110
Application*: IH
Target: LAMB2
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: CBYJL-1109
Application*: IP, IH, IF
Target: LAMB2
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: A5
Application*: IF, C, IP
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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