LDB1

LDB1 (LIM domain binding 1) is a protein that in humans is encoded by the LDB1 gene. LDB1 has been shown to interact with LMO4, TCF3, TAL1 and CBFA2T3.

LDB1

Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (By similarity).

Anterior/posterior axis specificationIEA:Ensembl
Cellular component assemblyIEA:Ensembl
Cerebellar Purkinje cell differentiationIEA:Ensembl
Epithelial structure maintenanceIEA:Ensembl
Gastrulation with mouth forming secondIEA:Ensembl
Hair follicle developmentIEA:Ensembl
Histone H3-K4 acetylationISS:BHF-UCL
Mesendoderm developmentIEA:Ensembl
Negative regulation of erythrocyte differentiationISS:UniProtKB
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Nervous system developmentManual Assertion Based On ExperimentIBA:GO_Central
Neuron differentiationISS:UniProtKB
Positive regulation of cell adhesionIEA:Ensembl
Positive regulation of hemoglobin biosynthetic processISS:BHF-UCL
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of cell migrationISS:UniProtKB
Regulation of focal adhesion assemblyISS:UniProtKB
Regulation of kinase activityISS:UniProtKB
Regulation of transcription elongation from RNA polymerase II promoterISS:BHF-UCL
Somatic stem cell population maintenanceIEA:Ensembl
Transcription by RNA polymerase IIIEA:Ensembl
Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear peripheryISS:BHF-UCL
Wnt signaling pathwayIEA:Ensembl

Nucleus

Ubiquitinated by RLIM/RNF12, leading to its degradation by the proteasome.