LDB1

LDB1 (LIM domain binding 1) is a protein that in humans is encoded by the LDB1 gene. LDB1 has been shown to interact with LMO4, TCF3, TAL1 and CBFA2T3.

Full Name

LDB1

Function

Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (By similarity).

Biological Process

Anterior/posterior axis specificationIEA:Ensembl
Cellular component assemblyIEA:Ensembl
Cerebellar Purkinje cell differentiationIEA:Ensembl
Epithelial structure maintenanceIEA:Ensembl
Gastrulation with mouth forming secondIEA:Ensembl
Hair follicle developmentIEA:Ensembl
Histone H3-K4 acetylationISS:BHF-UCL
Mesendoderm developmentIEA:Ensembl
Negative regulation of erythrocyte differentiationISS:UniProtKB
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Nervous system developmentManual Assertion Based On ExperimentIBA:GO_Central
Neuron differentiationISS:UniProtKB
Positive regulation of cell adhesionIEA:Ensembl
Positive regulation of hemoglobin biosynthetic processISS:BHF-UCL
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of cell migrationISS:UniProtKB
Regulation of focal adhesion assemblyISS:UniProtKB
Regulation of kinase activityISS:UniProtKB
Regulation of transcription elongation from RNA polymerase II promoterISS:BHF-UCL
Somatic stem cell population maintenanceIEA:Ensembl
Transcription by RNA polymerase IIIEA:Ensembl
Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear peripheryISS:BHF-UCL
Wnt signaling pathwayIEA:Ensembl

Cellular Location

Nucleus

PTM

Ubiquitinated by RLIM/RNF12, leading to its degradation by the proteasome.