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LGALS1

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation.
Full Name
LGALS1
Function
Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.
Biological Process
Apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Cell-cell adhesionManual Assertion Based On ExperimentIDA:ComplexPortal
Myoblast differentiationIEA:Ensembl
Plasma cell differentiationIEA:Ensembl
Positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentHMP:UniProtKB
Positive regulation of inflammatory responseManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of viral entry into host cellManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of apoptotic processManual Assertion Based On ExperimentTAS:UniProtKB
T cell costimulationIEA:Ensembl
Cellular Location
Secreted, extracellular space, extracellular matrix
Cytoplasm
Secreted
Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion.

Anti-LGALS1 antibodies

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Target: Lgals1
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYJL-2447
Application*: C, WB
Target: Lgals1
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYJL-2446
Application*: WB, IH
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG1, λ
Specificity: Human
Clone: GAL1/1831
Application*: WB, F, E, IF, P, MC
Target: LGALS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Cattle, Human, Mouse, Pig, Rat
Clone: CBFYH-3287
Application*: F, WB, P
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2615
Application*: P, WB
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2616
Application*: WB, IH
Target: LGALS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1490
Application*: IP, WB
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG2b, λ
Specificity: Human
Clone: 1E8-1B2
Application*: E, IF, IP, WB
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1491
Application*: E, WB, P, F
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1492
Application*: IP, WB
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 24CT661-4-3
Application*: P, WB
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 24CT661-4-4
Application*: E, WB
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6C8.4-1
Application*: IC, IF, WB
Target: LGALS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1494
Application*: E
Target: LGALS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1495
Application*: IC, P, IP, WB
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG1, λ
Specificity: Human
Clone: CBYJL-1496
Application*: E, WB, P, IF, IC, F
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1497
Application*: E
Target: LGALS1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBYJL-1499
Application*: E, F
Target: LGALS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1500
Application*: P
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG
Specificity: Cattle
Clone: CBYCL-252
Application*: WB, IC, P, C, E
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYCL-253
Application*: E, IH, WB
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBYCL-254
Application*: WB, IC, P, C, E
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBYCL-255
Application*: E, IC, WB
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG2b, λ
Specificity: Human
Clone: 1A8
Application*: WB, E
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8A12
Application*: WB, P
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CF267
Application*: ELISA, WB, IHC
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 214
Application*: ELISA, IHC, WB
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10i45
Application*: E, WB
Target: LGALS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 1
Application*: WB
Target: LGALS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Cattle, Human, Mouse, Pig, Rat
Clone: SP247
Application*: F
Target: LGALS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-3071
Application*: IC
Target: Lgals1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBYJL-2449
Application*: E
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBLG1-2340
Application*: E
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-2339
Application*: E
Target: LGALS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2337
Application*: EC
Target: LGALS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2335
Application*: E, ED
Target: LGALS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2334
Application*: WB
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBLG1-2333
Application*: E (IA), WB
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2332
Application*: WB
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2331
Application*: P
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-2330
Application*: E, WB
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBLG1-2329
Application*: WB
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBLG1-2328
Application*: WB
Target: LGALS1
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: RM0081-9J26
Application*: WB
Target: LGALS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D608T
Application*: P
Target: LGALS1
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 9J26
Application*: IH, WB
Target: LGALS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 8
Application*: E
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 24CT661.4.3
Application*: WB
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 2
Application*: WB
Target: LGALS1
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 14L452
Application*: IH, WB
Target: Lgals1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBYJL-2448
Application*: E, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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