LGALS1
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation.
Full Name
LGALS1
Function
Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.
Biological Process
Apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Cell-cell adhesionManual Assertion Based On ExperimentIDA:ComplexPortal
Myoblast differentiationIEA:Ensembl
Plasma cell differentiationIEA:Ensembl
Positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentHMP:UniProtKB
Positive regulation of inflammatory responseManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of viral entry into host cellManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of apoptotic processManual Assertion Based On ExperimentTAS:UniProtKB
T cell costimulationIEA:Ensembl
Cell-cell adhesionManual Assertion Based On ExperimentIDA:ComplexPortal
Myoblast differentiationIEA:Ensembl
Plasma cell differentiationIEA:Ensembl
Positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentHMP:UniProtKB
Positive regulation of inflammatory responseManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of viral entry into host cellManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of apoptotic processManual Assertion Based On ExperimentTAS:UniProtKB
T cell costimulationIEA:Ensembl
Cellular Location
Secreted, extracellular space, extracellular matrix
Cytoplasm
Secreted
Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion.
Cytoplasm
Secreted
Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion.
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Anti-LGALS1 antibodies
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CompareTarget: LGALS1
Host: Mouse
Antibody Isotype: IgG1, λ
Specificity: Human
Clone: GAL1/1831
Application*: WB, F, E, IF, P, MC
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 214
Application*: ELISA, IHC, WB
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CF267
Application*: ELISA, WB, IHC
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8A12
Application*: WB, P
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG2b, λ
Specificity: Human
Clone: 1A8
Application*: WB, E
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBLG1-2340
Application*: E
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-2339
Application*: E
Target: LGALS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2337
Application*: EC
Target: LGALS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2335
Application*: E, ED
Target: LGALS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2334
Application*: WB
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBLG1-2333
Application*: E (IA), WB
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2332
Application*: WB
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2331
Application*: P
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-2330
Application*: E, WB
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBLG1-2329
Application*: WB
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBLG1-2328
Application*: WB
Target: LGALS1
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: RM0081-9J26
Application*: WB
Target: LGALS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D608T
Application*: P
Target: LGALS1
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 9J26
Application*: IH, WB
Target: LGALS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 8
Application*: E
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 24CT661.4.3
Application*: WB
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 2
Application*: WB
Target: LGALS1
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 14L452
Application*: IH, WB
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10i45
Application*: E, WB
Target: LGALS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 1
Application*: WB
Target: LGALS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Cattle, Human, Mouse, Pig, Rat
Clone: SP247
Application*: F
Target: LGALS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-3071
Application*: IC
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBYCL-255
Application*: E, IC, WB
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBYCL-254
Application*: WB, IC, P, C, E
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYCL-253
Application*: E, IH, WB
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG
Specificity: Cattle
Clone: CBYCL-252
Application*: WB, IC, P, C, E
Target: Lgals1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBYJL-2449
Application*: E
Target: Lgals1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBYJL-2448
Application*: E, WB
Target: Lgals1
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYJL-2447
Application*: C, WB
Target: Lgals1
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYJL-2446
Application*: WB, IH
Target: LGALS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1500
Application*: P
Target: LGALS1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBYJL-1499
Application*: E, F
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1497
Application*: E
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG1, λ
Specificity: Human
Clone: CBYJL-1496
Application*: E, WB, P, IF, IC, F
Target: LGALS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1495
Application*: IC, P, IP, WB
Target: LGALS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1494
Application*: E
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6C8.4-1
Application*: IC, IF, WB
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 24CT661-4-4
Application*: E, WB
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 24CT661-4-3
Application*: P, WB
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1492
Application*: IP, WB
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1491
Application*: E, WB, P, F
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG2b, λ
Specificity: Human
Clone: 1E8-1B2
Application*: E, IF, IP, WB
Target: LGALS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1490
Application*: IP, WB
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2616
Application*: WB, IH
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2615
Application*: P, WB
Target: LGALS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Cattle, Human, Mouse, Pig, Rat
Clone: CBFYH-3287
Application*: F, WB, P
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 5G8
Application*: E, F
Target: LGALS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4748
Application*: IH, F
Target: LGALS1
Specificity: Human
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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