Human Recombinant LGALS1 protein (V2LY-0526-LY4242)

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Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host
E. coli
Protein Species
Human
Protein Construction
This product is Human Recombinant LGALS1 protein consist of Amino Acid: 1-135 and predicts a molecular mass of 15 kDa.
Molecule Mass
15 kDa
Sequence
Amino Acid: 1-135
Species
Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>98% as determined by SDS-PAGE
Endotoxin
Please contact us for more information.
Format
Lyophilized
Reconstitution
Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.
Buffer
Lyophilized from sterile
Preservative
None
Storage
Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
More Infomation

Target

Full Name
LGALS1
Function
Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.
Biological Process
Apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Cell-cell adhesionManual Assertion Based On ExperimentIDA:ComplexPortal
Myoblast differentiationIEA:Ensembl
Plasma cell differentiationIEA:Ensembl
Positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentHMP:UniProtKB
Positive regulation of inflammatory responseManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of viral entry into host cellManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of apoptotic processManual Assertion Based On ExperimentTAS:UniProtKB
T cell costimulationIEA:Ensembl
Cellular Location
Secreted, extracellular space, extracellular matrix
Cytoplasm
Secreted
Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion.

Triguero-Martínez, A., Roy-Vallejo, E., Montes, N., de la Fuente, H., Ortiz, A. M., Castañeda, S., ... & Lamana, A. (2022). Genetic LGALS1 Variants Are Associated with Heterogeneity in Galectin-1 Serum Levels in Patients with Early Arthritis. International Journal of Molecular Sciences, 23(13), 7181.

Sun, H., Zhang, H., Yan, Y., Li, Y., Che, G., Zhou, C., ... & Ma, H. (2022). NCAPG promotes the oncogenesis and progression of non-small cell lung cancer cells through upregulating LGALS1 expression. Molecular cancer, 21(1), 55.

Cai, Z., Yin, K., Liu, Q., Liu, M., Yang, X., & Cui, L. (2022). Association between abnormal expression and methylation of LGALS1 in amyotrophic lateral sclerosis. Brain Research, 1792, 148022.

Ruvolo, P., Ma, H., Ruvolo, V., Zhang, X., Post, S., & Andreeff, M. (2020). AML-044: LGALS1 Acts as a Pro-Survival Molecule in AML. Clinical Lymphoma Myeloma and Leukemia, 20, S176-S177.

Ruvolo, P. P., Ma, H., Ruvolo, V. R., Zhang, X., Post, S. M., & Andreeff, M. (2020). LGALS1 acts as a pro-survival molecule in AML. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 1867(10), 118785.

Li, Y., Yang, S., Yue, H., Yuan, D., Li, L., Zhao, J., & Zhao, L. (2020). Unraveling LGALS1 as a potential immune checkpoint and a predictor of the response to anti-PD1 therapy in clear cell renal carcinoma. Pathology & Oncology Research, 26, 1451-1458.

Chen, Q., Han, B., Meng, X., Duan, C., Yang, C., Wu, Z., ... & Cai, J. (2019). Immunogenomic analysis reveals LGALS1 contributes to the immune heterogeneity and immunosuppression in glioma. International journal of cancer, 145(2), 517-530.

Li, J. M., Tseng, C. W., Lin, C. C., Law, C. H., Chien, Y. A., Kuo, W. H., ... & Chan, H. L. (2018). Upregulation of LGALS1 is associated with oral cancer metastasis. Therapeutic Advances in Medical Oncology, 10, 1758835918794622.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant LGALS1 protein, His Tag (CAT#: V2LY-0526-LY4243)

Mouse Recombinant LGALS1 protein (CAT#: V2LY-0526-LY8350)

Rat Recombinant LGALS1 protein (CAT#: V2LY-0526-LY9389)

LGALS1 Matched Antibody Pair (687) (CAT#: APMAB-687LY)

Antibody Pairs

LGALS1 Matched Antibody Pair (687) (CAT#: APMAB-687LY)

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Rabbit Anti-LGALS1 Recombinant Antibody (CBLG1-2334) (CAT#: CBMAB-G6208-LY)

Mouse Anti-LGALS1 Recombinant Antibody (214) (CAT#: CBMAB-AP2984LY)

Mouse Anti-LGALS1 Recombinant Antibody (CBYJL-1497) (CAT#: CBMAB-L1241-YJ)

Rabbit Anti-LGALS1 Recombinant Antibody (CBYJL-1490) (CAT#: CBMAB-L1230-YJ)

Rabbit Anti-LGALS1 (C-terminus) Monoclonal Antibody (CBFYH-3287) (CAT#: CBMAB-H3652-FY)

Rabbit Anti-LGALS1 Recombinant Antibody (CBLG1-2337) (CAT#: CBMAB-G6211-LY)

Mouse Anti-LGALS1 Recombinant Antibody (24CT661-4-4) (CAT#: CBMAB-L1235-YJ)

Mouse Recombinant LGALS1 protein (CAT#: V2LY-0526-LY8350)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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