LRRC4B
LRRC4B (Leucine Rich Repeat Containing 4B) is a Protein Coding gene. Among its related pathways are Cell adhesion molecules (CAMs). Gene Ontology (GO) annotations related to this gene include signaling receptor binding. An important paralog of this gene is LRRC4C.
Full Name
leucine rich repeat containing 4B
Function
Synaptic adhesion protein. Regulates the formation of excitatory synapses. The trans-synaptic adhesion between LRRC4B and PTPRF regulates the formation of excitatory synapses in a bidirectional manner (By similarity).
Biological Process
Positive regulation of synapse assemblyISS:BHF-UCL
Regulation of postsynaptic density assemblyManual Assertion Based On ExperimentIBA:GO_Central
Regulation of presynapse assemblyManual Assertion Based On ExperimentIBA:GO_Central
Synaptic membrane adhesionManual Assertion Based On ExperimentIBA:GO_Central
Regulation of postsynaptic density assemblyManual Assertion Based On ExperimentIBA:GO_Central
Regulation of presynapse assemblyManual Assertion Based On ExperimentIBA:GO_Central
Synaptic membrane adhesionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Membrane
Cell junction, synapse, presynaptic cell membrane
Cell junction, synapse, presynaptic cell membrane
Topology
Extracellular: 36-576
Helical: 577-597
Cytoplasmic: 598-713
Helical: 577-597
Cytoplasmic: 598-713
PTM
N-glycosylated. O-glycosylated; contains sialic acid.
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Anti-LRRC4B antibodies
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Target: LRRC4B
Sensitivity: 0.023 ng/mL
Detection Range: 0.05-20 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: LRRC4B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-1131
Application*: IH
Target: LRRC4B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJN-1130
Application*: WB
Target: LRRC4B
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYJL-2018
Application*: WB, E, P
Target: LRRC4B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-2017
Application*: P
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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