LRRK1

LRRK1 is a leucine-rich repeat kinase and a GDP/GTP binding protein. LRRK1 is thought to play a role in the regulation of bone mass. Mice lacking a similar gene showed severe osteopetrosis, increased bone mineralization and decreased bone resorption.

leucine-rich repeat kinase 1

Bone resorptionIEA:Ensembl
Negative regulation of peptidyl-tyrosine phosphorylationIEA:Ensembl
Osteoclast developmentIEA:Ensembl
Positive regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIGI:ParkinsonsUK-UCL
Positive regulation of intracellular signal transductionIEA:Ensembl
Positive regulation of peptidyl-tyrosine phosphorylationIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Cytoplasm