Human Recombinant LRRK1, Active protein, GST Tag (V2LY-0526-LY5370)

Name: Human Recombinant LRRK1, Active protein, GST Tag
SKU: V2LY-0526-LY5370
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant LRRK1, Active protein, GST Tag consist of Amino Acid: 622-1610 and predicts a molecular mass of 139 kDa.

Molecule Mass

139 kDa

Sequence

Amino Acid: 622-1610

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

Tris, NaCl, Glutathione, EDTA, DTT, PMSF, Glycerol

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

leucine-rich repeat kinase 1

Biological Process

Bone resorptionIEA:Ensembl
Negative regulation of peptidyl-tyrosine phosphorylationIEA:Ensembl
Osteoclast developmentIEA:Ensembl
Positive regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIGI:ParkinsonsUK-UCL
Positive regulation of intracellular signal transductionIEA:Ensembl
Positive regulation of peptidyl-tyrosine phosphorylationIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm

Reimer, J. M., Dickey, A. M., Lin, Y. X., Abrisch, R. G., Mathea, S., Chatterjee, D., ... & Leschziner, A. E. (2023). Structure of LRRK1 and mechanisms of autoinhibition and activation. Nature Structural & Molecular Biology, 1-11.

Hanafusa, H., Fujita, K., Kamio, M., Iida, S., Tamura, Y., Hisamoto, N., & Matsumoto, K. (2023). LRRK1 functions as a scaffold for PTP1B-mediated EGFR sorting into ILVs at the ER–endosome contact site. Journal of Cell Science, 136(6), jcs260566.

Malik, A. U., Karapetsas, A., Nirujogi, R. S., Chatterjee, D., Phung, T. K., Wightman, M., ... & Alessi, D. R. (2022). PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain. Biochemical Journal, 479(18), 1941-1965.

Fujita, K., Kedashiro, S., Yagi, T., Hisamoto, N., Matsumoto, K., & Hanafusa, H. (2022). The ULK complex–LRRK1 axis regulates Parkin-mediated mitophagy via Rab7 Ser-72 phosphorylation. Journal of Cell Science, 135(23), jcs260395.

Malik, A. U., Karapetsas, A., Nirujogi, R. S., Mathea, S., Chatterjee, D., Pal, P., ... & Alessi, D. R. (2021). Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms. Biochemical Journal, 478(3), 553-578.

Li, S., Guo, W., Geng, H., Wang, C., Yang, S., & Xu, X. (2020). LINC00511 exacerbated T-cell acute lymphoblastic leukemia via miR-195-5p/LRRK1 axis. Bioscience Reports, 40(5), BSR20193631.

Howaldt, A., Hennig, A. F., Rolvien, T., Rössler, U., Stelzer, N., Knaus, A., ... & Kornak, U. (2020). Adult osteosclerotic metaphyseal dysplasia with progressive osteonecrosis of the jaws and abnormal bone resorption pattern due to a LRRK1 splice site mutation. Journal of Bone and Mineral Research, 35(7), 1322-1332.

Hanafusa, H., Yagi, T., Ikeda, H., Hisamoto, N., Nishioka, T., Kaibuchi, K., ... & Matsumoto, K. (2019). LRRK1 phosphorylation of Rab7 at S72 links trafficking of EGFR-containing endosomes to its effector RILP. Journal of cell science, 132(11), jcs228809.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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