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LYPLA2

Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet. [provided by RefSeq]

Full Name

lysophospholipase II

Function

Acts as a acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS (PubMed:21152083, PubMed:28826475).
Deacylates GAP43 (PubMed:21152083).
Mediates depalmitoylation of ZDHHC6 (PubMed:28826475).
Has lysophospholipase activity (PubMed:25301951).
Hydrolyzes prostaglandin glycerol esters (PG-Gs) in the following order prostaglandin D2-glycerol ester (PGD2-G)> prostaglandin E2 glycerol ester (PGE2-G)> prostaglandin F2-alpha-glycerol ester (PGF2-alpha-G) (PubMed:25301951).
Hydrolyzes 1-arachidonoylglycerol but not 2-arachidonoylglycerol or arachidonoylethanolamide (PubMed:25301951).

Biological Process

Acylglycerol catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Axon guidanceTAS:Reactome
Fatty acid metabolic processIEA:UniProtKB-KW
Prostaglandin catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Protein depalmitoylationManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm

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Anti-LYPLA2 antibodies

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Mouse Anti-LYPLA2 Recombinant Antibody (CBYCL-598) (CBMAB-L0499-YC)

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Target: LYPLA2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBYCL-598

Application*: E, WB

Mouse Anti-LYPLA2 Recombinant Antibody (CBYJL-2253) (CBMAB-L2513-YJ)

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Target: LYPLA2

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJL-2253

Application*: WB, IP, IF, E

Mouse Anti-LYPLA2 Recombinant Antibody (CBYJL-2251) (CBMAB-L2510-YJ)

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Target: LYPLA2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYJL-2251

Application*: E

Human Recombinant LYPLA2 protein, His Tag (V2LY-0526-LY5410)

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Target: LYPLA2

Expressed Host: E. coli

Sequence: Amino Acid: 1-231

Tag: His Tag

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Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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