LYPLA2

Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet. [provided by RefSeq]

lysophospholipase II

Acts as a acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS (PubMed:21152083, PubMed:28826475).
Deacylates GAP43 (PubMed:21152083).
Mediates depalmitoylation of ZDHHC6 (PubMed:28826475).
Has lysophospholipase activity (PubMed:25301951).
Hydrolyzes prostaglandin glycerol esters (PG-Gs) in the following order prostaglandin D2-glycerol ester (PGD2-G)> prostaglandin E2 glycerol ester (PGE2-G)> prostaglandin F2-alpha-glycerol ester (PGF2-alpha-G) (PubMed:25301951).
Hydrolyzes 1-arachidonoylglycerol but not 2-arachidonoylglycerol or arachidonoylethanolamide (PubMed:25301951).

Acylglycerol catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Axon guidanceTAS:Reactome
Fatty acid metabolic processIEA:UniProtKB-KW
Prostaglandin catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Protein depalmitoylationManual Assertion Based On ExperimentIDA:UniProtKB

Cytoplasm