Mouse Anti-LYPLA2 Recombinant Antibody (CBYJL-2251) (CBMAB-L2510-YJ)

Name: Mouse Anti-LYPLA2 Recombinant Antibody (CBYJL-2251)
SKU: CBMAB-L2510-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

CBYJL-2251

Application

ELISA

Immunogen

Recombinant Human LYPLA2 protein.

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

lysophospholipase II

Introduction

Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet. It hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS, mediates depalmitoylation of ZDHHC6. It has lysophospholipase activity (By similarity).

Entrez Gene ID

11313

UniProt ID

O95372

Alternative Names

APT2; APT-2; DJ886K2.4

Function

Acts as a acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS (PubMed:21152083, PubMed:28826475).
Deacylates GAP43 (PubMed:21152083).
Mediates depalmitoylation of ZDHHC6 (PubMed:28826475).
Has lysophospholipase activity (PubMed:25301951).
Hydrolyzes prostaglandin glycerol esters (PG-Gs) in the following order prostaglandin D2-glycerol ester (PGD2-G)> prostaglandin E2 glycerol ester (PGE2-G)> prostaglandin F2-alpha-glycerol ester (PGF2-alpha-G) (PubMed:25301951).
Hydrolyzes 1-arachidonoylglycerol but not 2-arachidonoylglycerol or arachidonoylethanolamide (PubMed:25301951).

Biological Process

Acylglycerol catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Axon guidanceTAS:Reactome
Fatty acid metabolic processIEA:UniProtKB-KW
Prostaglandin catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Protein depalmitoylationManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

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Mouse Anti-LYPLA2 Recombinant Antibody (CBYJL-2253) (CAT#: CBMAB-L2513-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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