MAEL

MAEL (Maelstrom Spermatogenic Transposon Silencer) is a Protein Coding gene. Among its related pathways are Mitotic Prophase and Gene Expression.

Full Name

MAELSTROM SPERMATOGENIC TRANSPOSON SILENCER

Function

Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage (By similarity).

Biological Process

Cell differentiationIEA:UniProtKB-KW
Cell morphogenesisIEA:Ensembl
DNA methylation involved in gamete generationISS:UniProtKB
FertilizationIEA:Ensembl
Gene silencing by RNAISS:UniProtKB
Homologous chromosome pairing at meiosisIEA:Ensembl
Intrinsic apoptotic signaling pathway in response to DNA damageIEA:Ensembl
Male meiotic nuclear divisionManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of apoptotic processIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIBA:GO_Central
piRNA metabolic processISS:UniProtKB
Regulation of gene silencing by miRNAIEA:InterPro
Regulation of organ growthIEA:Ensembl
SpermatogenesisISS:UniProtKB

Cellular Location

Cytoplasm
Nucleus
Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Specifically localizes to piP-bodies, a subset of the nuage which contains secondary piRNAs (By similarity).