Mouse Anti-MAEL Recombinant Antibody (CBFYM-1273) (CBMAB-M1432-FY)

Name: Mouse Anti-MAEL Recombinant Antibody (CBFYM-1273)
SKU: CBMAB-M1432-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-1273

Application

WB, IP, IF, ELISA

Specificity

Mouse

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

MAELSTROM SPERMATOGENIC TRANSPOSON SILENCER

Introduction

MAEL is a Protein Coding gene. Among its related pathways are Mitotic Prophase and Gene Expression.

Entrez Gene ID

84944

UniProt ID

Q96JY0

Alternative Names

Maelstrom Spermatogenic Transposon Silencer; Spermatogenesis Associated 35; Cancer/Testis Antigen 128; Testicular Tissue Protein Li 116; Maelstrom Homolog (Drosophila); Protein Maelstrom Homolog; Maelstrom Homolog; SPATA35; CT128

Function

Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage (By similarity).

Biological Process

Cell differentiationIEA:UniProtKB-KW
Cell morphogenesisIEA:Ensembl
DNA methylation involved in gamete generationISS:UniProtKB
FertilizationIEA:Ensembl
Gene silencing by RNAISS:UniProtKB
Homologous chromosome pairing at meiosisIEA:Ensembl
Intrinsic apoptotic signaling pathway in response to DNA damageIEA:Ensembl
Male meiotic nuclear divisionManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of apoptotic processIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIBA:GO_Central
piRNA metabolic processISS:UniProtKB
Regulation of gene silencing by miRNAIEA:InterPro
Regulation of organ growthIEA:Ensembl
SpermatogenesisISS:UniProtKB

Cellular Location

Cytoplasm
Nucleus
Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Specifically localizes to piP-bodies, a subset of the nuage which contains secondary piRNAs (By similarity).

Cheng, Y. S., Chen, H. Y., Lin, Y. C., Lin, Y. S., Yeh, Y. C., Yeh, Y. H., ... & Lin, S. C. (2023). The MAEL expression in mitochondria of human spermatozoa and the association with asthenozoospermia. Andrology.

Liu, S., Ma, X., Wang, Z., Lin, F., Li, M., Li, Y., ... & Deng, T. (2023). MAEL gene contributes to bovine testicular development through the m5C-mediated splicing. Iscience, 26(2).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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