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Mouse Anti-MAEL Recombinant Antibody (CBFYM-1273) (CBMAB-M1432-FY)

This product is mouse antibody that recognizes MAEL. The antibody CBFYM-1273 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all MAEL antibodies

Summary

Host Animal
Mouse
Specificity
Mouse
Clone
CBFYM-1273
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MAELSTROM SPERMATOGENIC TRANSPOSON SILENCER
Introduction
MAEL is a Protein Coding gene. Among its related pathways are Mitotic Prophase and Gene Expression.
Entrez Gene ID
84944
UniProt ID
Q96JY0
Alternative Names
Maelstrom Spermatogenic Transposon Silencer; Spermatogenesis Associated 35; Cancer/Testis Antigen 128; Testicular Tissue Protein Li 116; Maelstrom Homolog (Drosophila); Protein Maelstrom Homolog; Maelstrom Homolog; SPATA35; CT128
Function
Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage (By similarity).
Biological Process
Cell differentiationIEA:UniProtKB-KW
Cell morphogenesisIEA:Ensembl
DNA methylation involved in gamete generationISS:UniProtKB
FertilizationIEA:Ensembl
Gene silencing by RNAISS:UniProtKB
Homologous chromosome pairing at meiosisIEA:Ensembl
Intrinsic apoptotic signaling pathway in response to DNA damageIEA:Ensembl
Male meiotic nuclear divisionManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of apoptotic processIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIBA:GO_Central
piRNA metabolic processISS:UniProtKB
Regulation of gene silencing by miRNAIEA:InterPro
Regulation of organ growthIEA:Ensembl
SpermatogenesisISS:UniProtKB
Cellular Location
Cytoplasm
Nucleus
Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Specifically localizes to piP-bodies, a subset of the nuage which contains secondary piRNAs (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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