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MED7

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Two transcript variants encoding the same protein have been found for this gene.
Full Name
MED7
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Biological Process
Positive regulation of transcription elongation from RNA polymerase II promoter Source: ComplexPortal
Positive regulation of transcription initiation from RNA polymerase II promoter Source: ComplexPortal
Regulation of transcription by RNA polymerase II Source: MGI
RNA polymerase II preinitiation complex assembly Source: ComplexPortal
Stem cell population maintenance Source: Ensembl
Transcription initiation from RNA polymerase II promoter Source: ProtInc
Cellular Location
Nucleus
PTM
Constitutively sumoylated.
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Anti-MED7 antibodies

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Mouse Anti-MED7 Recombinant Antibody (2D7) (CBMAB-A1869-LY)

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Target: MED7
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: 2D7
Application*: WB, E
Datasheet SDS

Mouse Anti-MED7 Recombinant Antibody (3E7) (CBMAB-A1868-LY)

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Target: MED7
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3E7
Application*: WB, E
Datasheet SDS

Mouse Anti-MED7 Recombinant Antibody (CBYY-C2880) (CBMAB-C4323-YY)

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Target: MED7
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYY-C2880
Application*: E, WB
Datasheet SDS

Mouse Anti-MED7 (AA 9-33) Recombinant Antibody (CBFYC-2946) (CBMAB-C3022-FY)

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Target: MED7
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYC-2946
Application*: DB
Datasheet SDS

Mouse Anti-MED7 (AA 1-234) Recombinant Antibody (CBFYM-2018) (CBMAB-M2196-FY)

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Target: MED7
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-2018
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-MED7 (AA 1-233) Recombinant Antibody (CBFYM-2017) (CBMAB-M2195-FY)

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Target: MED7
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYM-2017
Application*: WB-Tr, SE, siRNA, E, WB-Re, WB-Ce
Datasheet SDS

Mouse Anti-MED7 Recombinant Antibody (CBFYM-0617) (CBMAB-M0751-FY)

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Target: MED7
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYM-0617
Application*: E, WB
Datasheet SDS

Mouse Anti-MED7 Recombinant Antibody (2217C6a) (CBMAB-C4415-LY)

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Target: MED7
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2217C6a
Application*: DB
Datasheet SDS

Mouse Anti-MED7 Antibody (1C4) (CBMAB-0653-YC)

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Target: MED7
Host: Mouse
Antibody Isotype: IgG2c
Specificity: Human
Clone: 1C4
Application*: E, IP
Datasheet SDS

Mouse Anti-MED7 Antibody (1B8) (CBMAB-0652-YC)

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Target: MED7
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1B8
Application*: E, IP
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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