Function
The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N6 position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis (PubMed:24316715, PubMed:24407421, PubMed:25719671, PubMed:29348140, PubMed:27373337, PubMed:27281194).
In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core (PubMed:27627798, PubMed:27373337, PubMed:27281194, PubMed:29348140).
N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing (PubMed:24316715, PubMed:24407421, PubMed:25719671).
M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation (By similarity).
In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization (By similarity).
M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity).
M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity).
Biological Process
Forebrain radial glial cell differentiation Source: UniProtKB
Gliogenesis Source: UniProtKB
mRNA catabolic process Source: Ensembl
mRNA destabilization Source: UniProtKB
mRNA methylation Source: UniProtKB
mRNA splicing, via spliceosome Source: UniProtKB
Negative regulation of hematopoietic progenitor cell differentiation Source: ARUK-UCL
Positive regulation of translation Source: ARUK-UCL
Spermatogenesis Source: UniProtKB
Stem cell population maintenance Source: UniProtKB
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Datasheet