MMEL1

The protein encoded by this gene is a member of the neutral endopeptidase (NEP) or membrane metallo-endopeptidase (MME) family. Family members play important roles in pain perception, arterial pressure regulation, phosphate metabolism and homeostasis. This protein is a type II transmembrane protein and is thought to be expressed as a secreted protein. This gene is expressed mainly in testis with weak expression in the brain, kidney, and heart.
Full Name
MEMBRANE METALLOENDOPEPTIDASE LIKE 1
Function
Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificity with MME and cleaves peptides at the same amide bond (By similarity).
Biological Process
Protein processing Source: GO_Central
Proteolysis Source: ARUK-UCL
Cellular Location
Secreted
Other locations
Membrane
Note: A secreted form produced by proteolytic cleavage also exists.
Topology
Cytoplasmic: 1-27
Helical: 28-48
Lumenal: 49-779
PTM
N-glycosylated.
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Anti-MMEL1 antibodies

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Mouse Anti-MMEL1 Recombinant Antibody (CBWJN-1141) (CBMAB-N0975-WJ)

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Target: MMEL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-1141
Application*: WB, IP
Datasheet SDS

Mouse Anti-MMEL1 Recombinant Antibody (2D2H5) (CBMAB-N0089-WJ)

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Target: MMEL1
Host: Mouse
Specificity: Human
Clone: 2D2H5
Application*: WB, F, E, IH, P, MC
Datasheet SDS

Mouse Anti-MMEL1 Recombinant Antibody (CBT3004) (V2LY-0625-LY159)

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Target: MMEL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3004
Application*: IH, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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