MMEL1

The protein encoded by this gene is a member of the neutral endopeptidase (NEP) or membrane metallo-endopeptidase (MME) family. Family members play important roles in pain perception, arterial pressure regulation, phosphate metabolism and homeostasis. This protein is a type II transmembrane protein and is thought to be expressed as a secreted protein. This gene is expressed mainly in testis with weak expression in the brain, kidney, and heart.

MEMBRANE METALLOENDOPEPTIDASE LIKE 1

Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificity with MME and cleaves peptides at the same amide bond (By similarity).

Protein processing Source: GO_Central
Proteolysis Source: ARUK-UCL

Secreted
Other locations
Membrane
Note: A secreted form produced by proteolytic cleavage also exists.

Cytoplasmic: 1-27
Helical: 28-48
Lumenal: 49-779

N-glycosylated.