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Mouse Anti-MMEL1 Recombinant Antibody (CBWJN-1141) (CBMAB-N0975-WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJN-1141
Antibody Isotype
IgG1
Application
WB, IP

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MEMBRANE METALLOENDOPEPTIDASE LIKE 1
Introduction
The protein encoded by this gene is a member of the neutral endopeptidase (NEP) or membrane metallo-endopeptidase (MME) family. Family members play important roles in pain perception, arterial pressure regulation, phosphate metabolism and homeostasis. This protein is a type II transmembrane protein and is thought to be expressed as a secreted protein. This gene is expressed mainly in testis with weak expression in the brain, kidney, and heart. [provided by RefSeq, Jul 2008]
Entrez Gene ID
79258
UniProt ID
Q495T6
Alternative Names
Membrane Metalloendopeptidase Like 1; Membrane Metallo-Endopeptidase-Like 2; Neprilysin II; Neprilysin-2; EC 3.4.24.11; NEP2(M); MMEL2; NEPII; NEP2;
Function
Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificity with MME and cleaves peptides at the same amide bond (By similarity).
Biological Process
Protein processing Source: GO_Central
Proteolysis Source: ARUK-UCL
Cellular Location
Secreted
Other locations
Membrane
Note: A secreted form produced by proteolytic cleavage also exists.
Topology
Cytoplasmic: 1-27
Helical: 28-48
Lumenal: 49-779
PTM
N-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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