MMP3
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
Full Name
Matrix Metallopeptidase 3
Function
Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.
Biological Process
Cellular response to nitric oxide Source: ParkinsonsUK-UCL
Cellular response to UV-A Source: UniProtKB
Collagen catabolic process Source: GO_Central
Extracellular matrix disassembly Source: Reactome
Extracellular matrix organization Source: GO_Central
Negative regulation of hydrogen peroxide metabolic process Source: ParkinsonsUK-UCL
Positive regulation of oxidative stress-induced cell death Source: ParkinsonsUK-UCL
Positive regulation of protein-containing complex assembly Source: ParkinsonsUK-UCL
Proteolysis Source: UniProtKB
Regulation of neuroinflammatory response Source: ARUK-UCL
Response to amyloid-beta Source: ARUK-UCL
Cellular response to UV-A Source: UniProtKB
Collagen catabolic process Source: GO_Central
Extracellular matrix disassembly Source: Reactome
Extracellular matrix organization Source: GO_Central
Negative regulation of hydrogen peroxide metabolic process Source: ParkinsonsUK-UCL
Positive regulation of oxidative stress-induced cell death Source: ParkinsonsUK-UCL
Positive regulation of protein-containing complex assembly Source: ParkinsonsUK-UCL
Proteolysis Source: UniProtKB
Regulation of neuroinflammatory response Source: ARUK-UCL
Response to amyloid-beta Source: ARUK-UCL
Cellular Location
Extracellular matrix
Involvement in disease
Coronary heart disease 6 (CHDS6):
A multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries.
A multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries.
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Anti-MMP3 antibodies
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CompareTarget: MMP3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: D7F5B
Application*: WB
Target: MMP3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A1154
Application*: IF, IHC, IP, WB
Target: MMP3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A1153
Application*: ICC, IHC, IP, WB
Target: MMP3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: A1152
Application*: ELISA, IHC, WB
Target: MMP3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A1151
Application*: ELISA, IF, IHC, IP, WB
Target: MMP3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A1150
Application*: ELISA, IHC, WB
Target: MMP3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 4C11
Application*: IP, E
Target: MMP3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1B4
Application*: E, IH, IF, IP, WB
Target: MMP3
Host: Mouse
Specificity: Rat
Clone: CBXS-0047
Application*: WB, IC, P, C, E
Target: MMP3
Host: Mouse
Specificity: Human
Clone: CBXS-0046
Application*: WB, IC, P, C, E
Target: MMP3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: M66
Application*: E, WB, IH
Target: MMP3
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBFYM-2407
Application*: E, WB
Target: MMP3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYM-2405
Application*: E, F, IC, IF, P, WB
Target: MMP3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-2404
Application*: IF, IH, IP, WB
Target: MMP3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2403
Application*: E, IH, WB
Target: MMP3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYM-2402
Application*: E, IP
Target: MMP3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2401
Application*: E, F, WB
Target: MMP3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-2400
Application*: P, WB
Target: MMP3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2399
Application*: WB, IH, IP
Target: MMP3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-0689
Application*: IF, WB
Target: MMP3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-0688
Application*: IF, IH, IP, WB
Target: MMP3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYM-0687
Application*: E, IH
Target: MMP3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Rabbit
Clone: CBFYM-0685
Application*: E, IH, WB
Target: MMP3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-0684
Application*: E, C, P, WB
Target: MMP3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0683
Application*: E, IF, IH, WB
Target: MMP3
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBFYM-0521
Application*: E, IC, WB
Target: MMP3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0415
Application*: IF, WB
Target: MMP3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYM-0277
Application*: IF
Target: MMP3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0171
Application*: F
Target: MMP3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: SB14d
Application*: E, P, C
Target: MMP3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2825
Application*: F
Target: MMP3
Specificity: Human
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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