MRI1

MRI1 functions in the methionine salvage pathway by catalyzing the interconversion of methylthioribose-1-phosphate and methythioribulose-1-phosphate. Elevated expression of the encoded protein is associated with metastatic melanoma and this protein promotes melanoma cell invasion independent of its enzymatic activity. Mutations in this gene may be associated with vanishing white matter disease (VMWD).
Full Name
Methylthioribose-1-Phosphate Isomerase 1
Function
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover.
Biological Process
L-methionine salvage from methylthioadenosine Source: GO_Central
L-methionine salvage from S-adenosylmethionine Source: UniProtKB-UniRule
Cellular Location
Nucleus
Cytoplasm
Other locations
Cell projection
Note: Primarily nuclear, but cytoplasmic in cancer cells, with enrichment at leading edge of the plasma membrane in late stage tumor cells.
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Anti-MRI1 antibodies

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Mouse Anti-MRI1 Recombinant Antibody (CBYJT-1475) (CBMAB-T0506-YJ)

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Target: MRI1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-1475
Application*: SE, E, WB
Datasheet SDS

Mouse Anti-MRI1 Recombinant Antibody (CBFYM-2548) (CBMAB-M2735-FY)

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Target: MRI1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2548
Application*: F, IF, IH, P, WB
Datasheet SDS

Mouse Anti-MRI1 Recombinant Antibody (CBFYM-0719) (CBMAB-M0861-FY)

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Target: MRI1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-0719
Application*: E, WB
Datasheet SDS

Mouse Anti-MRI1 Recombinant Antibody (CBFYE-1558) (CBMAB-E2207-FY)

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Target: MRI1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYE-1558
Application*: WB, F, IH, IF, P
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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