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Mouse Anti-MRI1 Recombinant Antibody (CBYJT-1475) (CBMAB-T0506-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to MRI1 (Methylthioribose-1-Phosphate Isomerase 1). The antibody can be used for immunoassay techniques, such as S-ELISA, ELISA, WB.
See all MRI1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-1475
Antibody Isotype
IgG1, κ
Application
S-ELISA, ELISA, WB

Basic Information

Immunogen
MGC3207 (AAH01703, 1 a.a. ~ 369 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-369

Target

Full Name
Methylthioribose-1-Phosphate Isomerase 1
Introduction
MRI1 functions in the methionine salvage pathway by catalyzing the interconversion of methylthioribose-1-phosphate and methythioribulose-1-phosphate. Elevated expression of the encoded protein is associated with metastatic melanoma and this protein promotes melanoma cell invasion independent of its enzymatic activity. Mutations in this gene may be associated with vanishing white matter disease (VMWD).
Entrez Gene ID
84245
UniProt ID
Q9BV20
Alternative Names
Methylthioribose-1-Phosphate Isomerase 1; Mediator Of RhoA-Dependent Invasion; Translation Initiation Factor EIF-2B Subunit Alpha/Beta/Delta-Like Protein; S-Methyl-5-Thioribose-1-Phosphate Isomerase 1; MTR-1-P Isomerase; EC 5.3.1.23; M1Pi; MRDI
Function
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover.
Biological Process
L-methionine salvage from methylthioadenosine Source: GO_Central
L-methionine salvage from S-adenosylmethionine Source: UniProtKB-UniRule
Cellular Location
Nucleus
Cytoplasm
Other locations
Cell projection
Note: Primarily nuclear, but cytoplasmic in cancer cells, with enrichment at leading edge of the plasma membrane in late stage tumor cells.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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