Mouse Anti-MRI1 Recombinant Antibody (CBYJT-1475) (CBMAB-T0506-YJ)

Name: Mouse Anti-MRI1 Recombinant Antibody (CBYJT-1475)
SKU: CBMAB-T0506-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYJT-1475

Application

S-ELISA, ELISA, WB

Immunogen

MGC3207 (AAH01703, 1 a.a. ~ 369 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.2

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 1-369

More Infomation

Target

Full Name

Methylthioribose-1-Phosphate Isomerase 1

Introduction

MRI1 functions in the methionine salvage pathway by catalyzing the interconversion of methylthioribose-1-phosphate and methythioribulose-1-phosphate. Elevated expression of the encoded protein is associated with metastatic melanoma and this protein promotes melanoma cell invasion independent of its enzymatic activity. Mutations in this gene may be associated with vanishing white matter disease (VMWD).

Entrez Gene ID

84245

UniProt ID

Q9BV20

Alternative Names

Methylthioribose-1-Phosphate Isomerase 1; Mediator Of RhoA-Dependent Invasion; Translation Initiation Factor EIF-2B Subunit Alpha/Beta/Delta-Like Protein; S-Methyl-5-Thioribose-1-Phosphate Isomerase 1; MTR-1-P Isomerase; EC 5.3.1.23; M1Pi; MRDI

Function

Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover.

Biological Process

L-methionine salvage from methylthioadenosine Source: GO_Central
L-methionine salvage from S-adenosylmethionine Source: UniProtKB-UniRule

Cellular Location

Nucleus
Cytoplasm
Other locations
Cell projection
Note: Primarily nuclear, but cytoplasmic in cancer cells, with enrichment at leading edge of the plasma membrane in late stage tumor cells.

Zhang, X., Zhen, D., Li, X., Yi, F., Zhang, Z., Yang, W., ... & He, Y. (2023). NOTCH2, ATIC, MRI1, SLC6A13, ATP13A2 Genetic Variations are Associated with Ventricular Septal Defect in the Chinese Tibetan Population Through Whole-Exome Sequencing. Pharmacogenomics and Personalized Medicine, 389-400.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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