MT1A

This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. The conserved cysteine residues co-ordinate metal ions using mercaptide linkages. These proteins act as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metals. Disruption of two metallothionein genes in mouse resulted in defects in protection against heavy metals, oxidative stress, immune reactions, carcinogens, and displayed obesity.

Full Name

METALLOTHIONEIN 1A

Function

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Biological Process

Cellular response to cadmium ion Source: UniProtKB
Cellular response to copper ion Source: GO_Central
Cellular response to zinc ion Source: UniProtKB
Cellular zinc ion homeostasis Source: GO_Central
Detoxification of copper ion Source: GO_Central
Negative regulation of growth Source: UniProtKB

Cellular Location

Cytosol
Nucleus
Other locations
cytoplasm