Mouse Anti-MT1A Recombinant Antibody (CBFYM-2703) (CBMAB-M2893-FY)

Name: Mouse Anti-MT1A Recombinant Antibody (CBFYM-2703)
SKU: CBMAB-M2893-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-2703

Application

WB, ICC, IHC-P, IHC-Fr, ELISA

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4, 50% glycerol

Preservative

0.02% Sodium azide

Concentration

0.5 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

METALLOTHIONEIN 1A

Introduction

This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. The conserved cysteine residues co-ordinate metal ions using mercaptide linkages. These proteins act as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metals. Disruption of two metallothionein genes in mouse resulted in defects in protection against heavy metals, oxidative stress, immune reactions, carcinogens, and displayed obesity.

Entrez Gene ID

4489

UniProt ID

P04731

Alternative Names

Metallothionein 1A; Metallothionein 1S; Metallothionein-IA; MT-1A; MT-IA; MT1S

Function

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Biological Process

Cellular response to cadmium ion Source: UniProtKB
Cellular response to copper ion Source: GO_Central
Cellular response to zinc ion Source: UniProtKB
Cellular zinc ion homeostasis Source: GO_Central
Detoxification of copper ion Source: GO_Central
Negative regulation of growth Source: UniProtKB

Cellular Location

Cytosol
Nucleus
Other locations
cytoplasm

Singh, P., Mitra, P., Goyal, T., Kumar, P. V. K., Sharma, S., & Sharma, P. (2020). Effect of metallothionein 1A rs8052394 polymorphism on lead, cadmium, zinc, and aluminum levels in factory workers. Toxicology and Industrial Health, 36(10), 816-822.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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