MTA3

MTA3 (Metastasis Associated 1 Family Member 3) is a Protein Coding gene. Diseases associated with MTA3 include Gastroesophageal Junction Adenocarcinoma. Among its related pathways are Gene Expression and Development NOTCH1-mediated pathway for NF-KB activity modulation. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is MTA1.

metastasis associated 1 family, member 3

Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6.

Chromatin remodeling Source: ComplexPortal
Histone deacetylation Source: ComplexPortal
Negative regulation of transcription, DNA-templated Source: CACAO
Negative regulation of transcription by RNA polymerase II Source: GO_Central
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of G2/M transition of mitotic cell cycle Source: Ensembl
Positive regulation of transcription, DNA-templated Source: ComplexPortal
Regulation of cell fate specification Source: ComplexPortal
Regulation of stem cell differentiation Source: ComplexPortal

Nucleus