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Mouse Anti-MTA3 (AA 416-515) Recombinant Antibody (CBFYM-2715) (CBMAB-M2908-FY)

This product is mouse antibody that recognizes MTA3. The antibody CBFYM-2715 can be used for immunoassay techniques such as: ELISA.
See all MTA3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2715
Antibody Isotype
IgG2a, k
Application
ELISA

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: LKMPTQSEEE KLSPSPTTED PRVRSHVSRQ AMQGMPVRNT GSPKSAVKTR QAFFLHTTYF TKFARQVCKN TLRLRQAARR PFVAINYAAI RAECKMLLNS
Specificity
Human
Antibody Isotype
IgG2a, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 416-515

Target

Full Name
metastasis associated 1 family, member 3
Introduction
MTA3 is a Protein Coding gene. Diseases associated with MTA3 include Gastroesophageal Junction Adenocarcinoma. Among its related pathways are Gene Expression and Development NOTCH1-mediated pathway for NF-KB activity modulation. Gene Ontology annotations related to this gene include DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is MTA1.
Entrez Gene ID
57504
UniProt ID
Q9BTC8
Alternative Names
Metastasis Associated 1 Family Member 3; Metastasis Associated Gene Family, Member 3; KIAA1266
Function
Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6.
Biological Process
Chromatin remodeling Source: ComplexPortal
Histone deacetylation Source: ComplexPortal
Negative regulation of transcription, DNA-templated Source: CACAO
Negative regulation of transcription by RNA polymerase II Source: GO_Central
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of G2/M transition of mitotic cell cycle Source: Ensembl
Positive regulation of transcription, DNA-templated Source: ComplexPortal
Regulation of cell fate specification Source: ComplexPortal
Regulation of stem cell differentiation Source: ComplexPortal
Cellular Location
Nucleus

Wang, B., Shen, X. Y., Pan, L. Y., Li, Z., Chen, C. J., Yao, Y. S., ... & Gao, W. (2023). The HDAC2–MTA3 interaction induces nonsmall cell lung cancer cell migration and invasion by targeting c‐Myc and cyclin D1. Molecular Carcinogenesis, 62(11), 1630-1644.

Liu, F., Chen, Z. Z., Zhao, J., Zhang, Y. Q., Ma, J., & Li, W. (2022). T2DM-elicited oxidative stress represses MTA3 expression in mouse Leydig cells. Reproduction, 163(5), 267-280.

Pertiwi, M. P., Listyorini, D., Susanto, H., & Handaya, A. Y. (2020, September). MTA3 gene expression as potential gene biomarker for epithelial mesenchymal transition (EMT) study in colorectal cancer (CRC) cases. In AIP Conference Proceedings (Vol. 2260, No. 1). AIP Publishing.

Du, L., Wang, L., Gan, J., Yao, Z., Lin, W., Li, J., ... & Zhang, H. (2019). MTA3 represses cancer stemness by targeting the SOX2OT/SOX2 Axis. Iscience, 22, 353-368.

Yao, Z., Du, L., Xu, M., Li, K., Guo, H., Ye, G., ... & Zhang, H. (2019). MTA3-SOX2 module regulates cancer stemness and contributes to clinical outcomes of tongue carcinoma. Frontiers in oncology, 9, 816.

Xiao, D., Zhang, Y., Wang, R., Fu, Y., Zhou, T., Diao, H., ... & Yang, B. (2019). Emodin alleviates cardiac fibrosis by suppressing activation of cardiac fibroblasts via upregulating metastasis associated protein 3. Acta Pharmaceutica Sinica B, 9(4), 724-733.

Liu, L., Qi, X., Gui, Y., Huo, H., Yang, X., & Yang, L. (2019). Overexpression of circ_0021093 circular RNA forecasts an unfavorable prognosis and facilitates cell progression by targeting the miR-766-3p/MTA3 pathway in hepatocellular carcinoma. Gene, 714, 143992.

Zhao, L., Wang, Y., & Liu, Q. (2019). Catalpol inhibits cell proliferation, invasion and migration through regulating miR-22-3p/MTA3 signalling in hepatocellular carcinoma. Experimental and molecular pathology, 109, 51-60.

Zhang, L., Cao, Y., Kou, X., Che, L., Zhou, X., Chen, G., & Zhao, J. (2019). Long non‐coding RNA HCG11 suppresses the growth of glioma by cooperating with the miR‐4425/MTA3 axis. The journal of gene medicine, 21(4), e3074.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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