MTMR1

This gene encodes a member of the myotubularin related family of proteins. Members of this family contain the consensus sequence for the active site of protein tyrosine phosphatases. Alternatively spliced variants have been described but their biological validity has not been determined. [provided by RefSeq]

myotubularin related protein 1

Lipid phosphatase that has high specificity for phosphatidylinositol 3-phosphate and has no activity with phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed:11733541, PubMed:27018598).

Activity with phosphatidylinositol (3,5)-bisphosphate is controversial; it has been shown by PubMed:27018598, while PubMed:11733541 find no activity with this substrate.

Phosphatidylinositol biosynthetic process Source: Reactome
Phosphatidylinositol dephosphorylation Source: UniProtKB
Regulation of phosphatidylinositol dephosphorylation Source: UniProtKB

Cytoplasm By similarity
Plasma membrane
Cell membrane