MUC5B

This gene encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. This family member is the major gel-forming mucin in mucus. It is a major contributor to the lubricating and viscoelastic properties of whole saliva, normal lung mucus and cervical mucus. This gene has been found to be up-regulated in some human diseases, including sinus mucosa of chronic rhinosinusitis (CRS), CRS with nasal polyposis, chronic obstructive pulmonary disease (COPD) and H. pylori-associated gastric disease, and it may be involved in the pathogenesis of these diseases. [provided by RefSeq, Jul 2010]
Full Name
Mucin 5B, Oligomeric Mucus/Gel-Forming
Function
Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus.
Cellular Location
Secreted
Involvement in disease
Interstitial lung disease 2 (ILD2):
A form of interstitial lung disease, a heterogeneous group of diseases affecting the distal part of the lung and characterized by a progressive remodeling of the alveolar interstitium. The disease spectrum ranges from idiopathic interstitial pneumonia or pneumonitis to idiopathic pulmonary fibrosis, that is associated with an increased risk of developing lung cancer. Clinical features of interstitial lung disease include dyspnea, clubbing of the fingers, and restrictive lung capacity. ILD2 inheritance is autosomal dominant.
PTM
Highly glycosylated. C-, N- and O-glycosylated. C-mannosylated in the Cys-rich subdomains probably on the first Trp residue of the WXXW motif. Highly O-glycosylated in the Ser/Thr-rich tandem repeat (TR) region. The repeat region is about 59% O-glycosylated with a high abundance of NeuAc2Hex1HexNac1-ol.
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Anti-MUC5B antibodies

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Mouse Anti-MUC5B Recombinant Antibody (A1253) (CBMAB-AP4927LY)

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Target: MUC5B
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A1253
Application*: ICC, IHC, IP, WB
Datasheet SDS

Recombinant Mouse Anti-MUC5B Recombinant Antibody (MUC5Bb) (CBMAB-XB0853-YC)

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Target: MUC5B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: MUC5Bb
Application*: E, IH, WB
Datasheet SDS

Recombinant Mouse Anti-MUC5B Recombinant Antibody (MUC5Ba) (CBMAB-XB0852-YC)

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Target: MUC5B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: MUC5Ba
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-MUC5B Recombinant Antibody (CBFYM-2820) (CBMAB-M3013-FY)

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Target: MUC5B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Rabbit
Clone: CBFYM-2820
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-MUC5B Recombinant Antibody (CBFYM-2819) (CBMAB-M3012-FY)

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Target: MUC5B
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYM-2819
Application*: WB, IC, C, P, E
Datasheet SDS

Mouse Anti-MUC5B (AA 4186-4295) Recombinant Antibody (CBFYM-2816) (CBMAB-M3009-FY)

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Target: MUC5B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-2816
Application*: E, WB
Datasheet SDS

Mouse Anti-MUC5B Recombinant Antibody (CBFYM-0198) (CBMAB-M0236-FY)

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Target: MUC5B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-0198
Application*: WB, E, IH
Datasheet SDS

Mouse Anti-MUC5B Recombinant Antibody (CBT3856) (V2LY-0625-LY1420)

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Target: MUC5B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3856
Application*: F
Datasheet SDS

Mouse Anti-MUC5B Recombinant Antibody (CBT3099) (V2LY-0625-LY1382)

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Target: MUC5B
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT3099
Application*: F
Datasheet SDS

Mouse Anti-MUC5B Recombinant Antibody (CBT3536) (V2LY-0625-LY1133)

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Target: MUC5B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3536
Application*: IH, F
Datasheet SDS

Mouse Anti-MUC5B Recombinant Antibody (CBT3499) (V2LY-0625-LY1132)

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Target: MUC5B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3499
Application*: F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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