Mouse Anti-MUC5B Recombinant Antibody (CBT3856) (V2LY-0625-LY1420)

Name: Mouse Anti-MUC5B Recombinant Antibody (CBT3856)
SKU: V2LY-0625-LY1420
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-MUC5B Recombinant Antibody (CBT3856) (V2LY-0625-LY1420) in ELISA

Mouse Anti-MUC5B Recombinant Antibody (CBT3856) (V2LY-0625-LY1420) in WB

Mouse Anti-MUC5B Recombinant Antibody (CBT3856) (V2LY-0625-LY1420) in FC

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBT3856

Application

Immunogen

Purified recombinant fragment of human MUC5B (AA: 5630-5757) expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
FC	1:200-1:400
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Mucin 5B, Oligomeric Mucus/Gel-Forming

Entrez Gene ID

727897

UniProt ID

Q9HC84

Function

Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus.

Cellular Location

Secreted

Involvement in disease

Interstitial lung disease 2 (ILD2):
A form of interstitial lung disease, a heterogeneous group of diseases affecting the distal part of the lung and characterized by a progressive remodeling of the alveolar interstitium. The disease spectrum ranges from idiopathic interstitial pneumonia or pneumonitis to idiopathic pulmonary fibrosis, that is associated with an increased risk of developing lung cancer. Clinical features of interstitial lung disease include dyspnea, clubbing of the fingers, and restrictive lung capacity. ILD2 inheritance is autosomal dominant.

PTM

Highly glycosylated. C-, N- and O-glycosylated. C-mannosylated in the Cys-rich subdomains probably on the first Trp residue of the WXXW motif. Highly O-glycosylated in the Ser/Thr-rich tandem repeat (TR) region. The repeat region is about 59% O-glycosylated with a high abundance of NeuAc2Hex1HexNac1-ol.

Tajiri, T., Matsumoto, H., Jinnai, M., Kanemitsu, Y., Nagasaki, T., Iwata, T., ... & Niimi, A. (2022). Pathophysiological relevance of sputum MUC5AC and MUC5B levels in patients with mild asthma. Allergology International, 71(2), 193-199.

Costain, G., Liu, Z., Mennella, V., Radicioni, G., Goczi, A. N., Albulescu, A., ... & Dell, S. D. (2022). Hereditary mucin deficiency caused by biallelic loss of function of MUC5B. American Journal of Respiratory and Critical Care Medicine, 205(7), 761-768.

Faruque, M., Wanschers, M., Ligtenberg, A. J., Laine, M. L., & Bikker, F. J. (2022). A review on the role of salivary MUC5B in oral health. Journal of Oral Biosciences.

Song, D., Iverson, E., Kaler, L., Boboltz, A., Scull, M. A., & Duncan, G. A. (2022). MUC5B mobilizes and MUC5AC spatially aligns mucociliary transport on human airway epithelium. Science Advances, 8(47), eabq5049.

Radicioni, G., Ceppe, A., Ford, A. A., Alexis, N. E., Barr, R. G., Bleecker, E. R., ... & Kesimer, M. (2021). Airway mucin MUC5AC and MUC5B concentrations and the initiation and progression of chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort. The Lancet Respiratory Medicine, 9(11), 1241-1254.

Carpenter, J., Wang, Y., Gupta, R., Li, Y., Haridass, P., Subramani, D. B., ... & Kesimer, M. (2021). Assembly and organization of the N-terminal region of mucin MUC5AC: Indications for structural and functional distinction from MUC5B. Proceedings of the National Academy of Sciences, 118(39), e2104490118.

Biondini, D., Cocconcelli, E., Bernardinello, N., Lorenzoni, G., Rigobello, C., Lococo, S., ... & Spagnolo, P. (2021). Prognostic role of MUC5B rs35705950 genotype in patients with idiopathic pulmonary fibrosis (IPF) on antifibrotic treatment. Respiratory research, 22, 1-9.

Zhang, Q., Wang, Y., Qu, D., Yu, J., & Yang, J. (2019). The possible pathogenesis of idiopathic pulmonary fibrosis considering MUC5B. BioMed research international, 2019.

Okuda, K., Chen, G., Subramani, D. B., Wolf, M., Gilmore, R. C., Kato, T., ... & Boucher, R. C. (2019). Localization of secretory mucins MUC5AC and MUC5B in normal/healthy human airways. American journal of respiratory and critical care medicine, 199(6), 715-727.

Kurche, J. S., Dobrinskikh, E., Hennessy, C. E., Huber, J., Estrella, A., Hancock, L. A., ... & Schwartz, D. A. (2019). Muc5b enhances murine honeycomb-like cyst formation. American journal of respiratory cell and molecular biology, 61(4), 544-546.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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