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Mouse Anti-MUC5B Recombinant Antibody (CBFYM-0198) (CBMAB-M0236-FY)

This product is mouse antibody that recognizes MUC5B. The antibody CBFYM-0198 can be used for immunoassay techniques such as: WB, ELISA, IHC.
See all MUC5B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-0198
Antibody Isotype
IgG1, k
Application
WB, ELISA, IHC

Basic Information

Immunogen
KLH conjugated peptide RNREQVGKF in 4 of the cysteine domains of the tandem repeat region was used to immunise Balb/c female mice
Specificity
Human
Antibody Isotype
IgG1, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Mucin 5B, Oligomeric Mucus/Gel-Forming
Introduction
This gene encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. This family member is the major gel-forming mucin in mucus. It is a major contributor to the lubricating and viscoelastic properties of whole saliva, normal lung mucus and cervical mucus. This gene has been found to be up-regulated in some human diseases, including sinus mucosa of chronic rhinosinusitis, CRS with nasal polyposis, chronic obstructive pulmonary disease and H. pylori-associated gastric disease, and it may be involved in the pathogenesis of these diseases.
Entrez Gene ID
727897
UniProt ID
Q9HC84
Alternative Names
Mucin 5B, Oligomeric Mucus/Gel-Forming; High Molecular Weight Salivary Mucin MG1; Mucin 5, Subtype B, Tracheobronchial; Sublingual Gland Mucin; MUC-5B; MUC5; Mucin-5 Subtype B, Tracheobronchial
Function
Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus.
Cellular Location
Secreted
Involvement in disease
Interstitial lung disease 2 (ILD2):
A form of interstitial lung disease, a heterogeneous group of diseases affecting the distal part of the lung and characterized by a progressive remodeling of the alveolar interstitium. The disease spectrum ranges from idiopathic interstitial pneumonia or pneumonitis to idiopathic pulmonary fibrosis, that is associated with an increased risk of developing lung cancer. Clinical features of interstitial lung disease include dyspnea, clubbing of the fingers, and restrictive lung capacity. ILD2 inheritance is autosomal dominant.
PTM
Highly glycosylated. C-, N- and O-glycosylated. C-mannosylated in the Cys-rich subdomains probably on the first Trp residue of the WXXW motif. Highly O-glycosylated in the Ser/Thr-rich tandem repeat (TR) region. The repeat region is about 59% O-glycosylated with a high abundance of NeuAc2Hex1HexNac1-ol.

Tajiri, T., Matsumoto, H., Jinnai, M., Kanemitsu, Y., Nagasaki, T., Iwata, T., ... & Niimi, A. (2022). Pathophysiological relevance of sputum MUC5AC and MUC5B levels in patients with mild asthma. Allergology International, 71(2), 193-199.

Costain, G., Liu, Z., Mennella, V., Radicioni, G., Goczi, A. N., Albulescu, A., ... & Dell, S. D. (2022). Hereditary mucin deficiency caused by biallelic loss of function of MUC5B. American Journal of Respiratory and Critical Care Medicine, 205(7), 761-768.

Faruque, M., Wanschers, M., Ligtenberg, A. J., Laine, M. L., & Bikker, F. J. (2022). A review on the role of salivary MUC5B in oral health. Journal of Oral Biosciences.

Song, D., Iverson, E., Kaler, L., Boboltz, A., Scull, M. A., & Duncan, G. A. (2022). MUC5B mobilizes and MUC5AC spatially aligns mucociliary transport on human airway epithelium. Science Advances, 8(47), eabq5049.

Radicioni, G., Ceppe, A., Ford, A. A., Alexis, N. E., Barr, R. G., Bleecker, E. R., ... & Kesimer, M. (2021). Airway mucin MUC5AC and MUC5B concentrations and the initiation and progression of chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort. The Lancet Respiratory Medicine, 9(11), 1241-1254.

Carpenter, J., Wang, Y., Gupta, R., Li, Y., Haridass, P., Subramani, D. B., ... & Kesimer, M. (2021). Assembly and organization of the N-terminal region of mucin MUC5AC: Indications for structural and functional distinction from MUC5B. Proceedings of the National Academy of Sciences, 118(39), e2104490118.

Biondini, D., Cocconcelli, E., Bernardinello, N., Lorenzoni, G., Rigobello, C., Lococo, S., ... & Spagnolo, P. (2021). Prognostic role of MUC5B rs35705950 genotype in patients with idiopathic pulmonary fibrosis (IPF) on antifibrotic treatment. Respiratory research, 22, 1-9.

Zhang, Q., Wang, Y., Qu, D., Yu, J., & Yang, J. (2019). The possible pathogenesis of idiopathic pulmonary fibrosis considering MUC5B. BioMed research international, 2019.

Okuda, K., Chen, G., Subramani, D. B., Wolf, M., Gilmore, R. C., Kato, T., ... & Boucher, R. C. (2019). Localization of secretory mucins MUC5AC and MUC5B in normal/healthy human airways. American journal of respiratory and critical care medicine, 199(6), 715-727.

Kurche, J. S., Dobrinskikh, E., Hennessy, C. E., Huber, J., Estrella, A., Hancock, L. A., ... & Schwartz, D. A. (2019). Muc5b enhances murine honeycomb-like cyst formation. American journal of respiratory cell and molecular biology, 61(4), 544-546.

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For research use only. Not intended for any clinical use.

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