MYOZ1

The protein encoded by this gene is primarily expressed in the skeletal muscle, and belongs to the myozenin family. Members of this family function as calcineurin-interacting proteins that help tether calcineurin to the sarcomere of cardiac and skeletal muscle. They play an important role in modulation of calcineurin signaling.
Full Name
myozenin 1
Function
Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.
Biological Process
Myofibril assembly Source: UniProtKB
Negative regulation of calcineurin-NFAT signaling cascade Source: BHF-UCL
Negative regulation of skeletal muscle tissue regeneration Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Sarcomere organization Source: BHF-UCL
Skeletal muscle fiber adaptation Source: BHF-UCL
Skeletal muscle tissue development Source: BHF-UCL
Wound healing Source: BHF-UCL
Cellular Location
Nucleus
Other locations
pseudopodium
Note: Localized to the nucleus and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2, FLNC and MYOT at the Z-lines of skeletal muscle.
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Anti-MYOZ1 antibodies

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Mouse Anti-MYOZ1 Recombinant Antibody (1E8) (CBMAB-A5755-LY)

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Target: MYOZ1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1E8
Application*: WB, E
Datasheet SDS

Mouse Anti-MYOZ1 (AA 106-299) Recombinant Antibody (CBFYM-3018) (CBMAB-M3213-FY)

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Target: MYOZ1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-3018
Application*: WB
Datasheet SDS

Mouse Anti-MYOZ1 Recombinant Antibody (CBFYM-3017) (CBMAB-M3212-FY)

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Target: MYOZ1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYM-3017
Application*: WB
Datasheet SDS

Mouse Anti-MYOZ1 (AA 200-298) Recombinant Antibody (CBFYM-3016) (CBMAB-M3211-FY)

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Target: MYOZ1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-3016
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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