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MYOZ1

The protein encoded by this gene is primarily expressed in the skeletal muscle, and belongs to the myozenin family. Members of this family function as calcineurin-interacting proteins that help tether calcineurin to the sarcomere of cardiac and skeletal muscle. They play an important role in modulation of calcineurin signaling.

Full Name

myozenin 1

Function

Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.

Biological Process

Myofibril assembly Source: UniProtKB
Negative regulation of calcineurin-NFAT signaling cascade Source: BHF-UCL
Negative regulation of skeletal muscle tissue regeneration Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Sarcomere organization Source: BHF-UCL
Skeletal muscle fiber adaptation Source: BHF-UCL
Skeletal muscle tissue development Source: BHF-UCL
Wound healing Source: BHF-UCL

Cellular Location

Nucleus
Other locations
pseudopodium
Note: Localized to the nucleus and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2, FLNC and MYOT at the Z-lines of skeletal muscle.

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Anti-MYOZ1 antibodies

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Mouse Anti-MYOZ1 Recombinant Antibody (1E8) (CBMAB-A5755-LY)

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Target: MYOZ1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 1E8

Application*: WB, E

Mouse Anti-MYOZ1 (AA 106-299) Recombinant Antibody (CBFYM-3018) (CBMAB-M3213-FY)

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Target: MYOZ1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYM-3018

Application*: WB

Mouse Anti-MYOZ1 Recombinant Antibody (CBFYM-3017) (CBMAB-M3212-FY)

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Target: MYOZ1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBFYM-3017

Application*: WB

Mouse Anti-MYOZ1 (AA 200-298) Recombinant Antibody (CBFYM-3016) (CBMAB-M3211-FY)

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Target: MYOZ1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYM-3016

Application*: E, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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