Mouse Anti-MYOZ1 (AA 200-298) Recombinant Antibody (CBFYM-3016) (CBMAB-M3211-FY)

Name: Mouse Anti-MYOZ1 (AA 200-298) Recombinant Antibody (CBFYM-3016)
SKU: CBMAB-M3211-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-3016

Application

ELISA, WB

Immunogen

Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: MELGIDLLAY GAKAELPKYK SFNRTAMPYG GYEKASKRMT FQMPKFDLGP LLSEPLVLYN QNLSNRPSFN RTPIPWLSSG EPVDYNVDIG IPLDGETEE

Specificity

Human

Antibody Isotype

IgG2a, k

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 200-298

More Infomation

Target

Full Name

myozenin 1

Introduction

The protein encoded by this gene is primarily expressed in the skeletal muscle, and belongs to the myozenin family. Members of this family function as calcineurin-interacting proteins that help tether calcineurin to the sarcomere of cardiac and skeletal muscle. They play an important role in modulation of calcineurin signaling.

Entrez Gene ID

58529

UniProt ID

Q9NP98

Alternative Names

Myozenin 1; Calsarcin-2; Filamin-, Actinin- And Telethonin-Binding Protein; MYOZ; Protein FATZ; Myozenin-1; Myozenin; CS-2; FATZ

Function

Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.

Biological Process

Myofibril assembly Source: UniProtKB
Negative regulation of calcineurin-NFAT signaling cascade Source: BHF-UCL
Negative regulation of skeletal muscle tissue regeneration Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Sarcomere organization Source: BHF-UCL
Skeletal muscle fiber adaptation Source: BHF-UCL
Skeletal muscle tissue development Source: BHF-UCL
Wound healing Source: BHF-UCL

Cellular Location

Nucleus
Other locations
pseudopodium
Note: Localized to the nucleus and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2, FLNC and MYOT at the Z-lines of skeletal muscle.

Lim, J. Y., Kim, E., Douglas, C. M., Wirianto, M., Han, C., Ono, K., ... & Yoo, S. H. (2022). The circadian E3 ligase FBXL21 regulates myoblast differentiation and sarcomere architecture via MYOZ1 ubiquitination and NFAT signaling. PLoS Genetics, 18(12), e1010574.

Fatchiyah, F., Rohmah, R. N., Triprisila, L. F., Virgirinia, R. P., Rahayudi, B., Kurnianingsih, N., ... & Abdul Razis, A. F. (2022). The Expression of Myoz1 and ApoB is Positively Correlated with Meat Quality of Broiler Chicken. Veterinary medicine international, 2022.

Zhou, T., Wu, Y., Bi, Y., Bai, H., Jiang, Y., Chen, G., ... & Wang, Z. (2022). MYOZ1 Gene Promotes Muscle Growth and Development in Meat Ducks. Genes, 13(9), 1574.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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