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Mouse Anti-MYOZ1 (AA 106-299) Recombinant Antibody (CBFYM-3018) (CBMAB-M3213-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-3018
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 106-299 of human MYOZ1(NP_067068) produced in E.coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA
Preservative
0.02% Sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 106-299

Target

Full Name
myozenin 1
Introduction
The protein encoded by this gene is primarily expressed in the skeletal muscle, and belongs to the myozenin family. Members of this family function as calcineurin-interacting proteins that help tether calcineurin to the sarcomere of cardiac and skeletal muscle. They play an important role in modulation of calcineurin signaling.
Entrez Gene ID
58529
UniProt ID
Q9NP98
Alternative Names
Myozenin 1; Calsarcin-2; Filamin-, Actinin- And Telethonin-Binding Protein; MYOZ; Protein FATZ; Myozenin-1; Myozenin; CS-2; FATZ
Function
Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.
Biological Process
Myofibril assembly Source: UniProtKB
Negative regulation of calcineurin-NFAT signaling cascade Source: BHF-UCL
Negative regulation of skeletal muscle tissue regeneration Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Sarcomere organization Source: BHF-UCL
Skeletal muscle fiber adaptation Source: BHF-UCL
Skeletal muscle tissue development Source: BHF-UCL
Wound healing Source: BHF-UCL
Cellular Location
Nucleus
Other locations
pseudopodium
Note: Localized to the nucleus and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2, FLNC and MYOT at the Z-lines of skeletal muscle.
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For research use only. Not intended for any clinical use.

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