NCAPD3

Condensin complexes I and II play essential roles in mitotic chromosome assembly and segregation. Both condensins contain 2 invariant structural maintenance of chromosome (SMC) subunits, SMC2 (MIM 605576) and SMC4 (MIM 605575), but they contain different sets of non-SMC subunits. NCAPD3 is 1 of 3 non-SMC subunits that define condensin II (Ono et al., 2003 [PubMed 14532007]).[supplied by OMIM, Mar 2008]
Full Name
Non-SMC Condensin II Complex Subunit D3
Function
Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis (PubMed:14532007).

May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959).
Biological Process
Cell division Source: UniProtKB-KW
Meiotic chromosome condensation Source: GO_Central
Mitotic chromosome condensation Source: UniProtKB
Cellular Location
Nucleus
Involvement in disease
Microcephaly 22, primary, autosomal recessive (MCPH22):
A form of microcephaly, a disease defined as a head circumference more than 3 standard deviations below the age, sex and ethnically matched mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small.
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Anti-NCAPD3 antibodies

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Mouse Anti-NCAPD3 Recombinant Antibody (1D5) (CBMAB-A4674-LY)

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Target: NCAPD3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1D5
Application*: WB, E
Datasheet SDS

Mouse Anti-NCAPD3 Recombinant Antibody (CBYY-C2700) (CBMAB-C4141-YY)

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Target: NCAPD3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2700
Application*: IP, WB
Datasheet SDS

Rabbit Anti-NCAPD3 Recombinant Antibody (D3H6L) (CBMAB-N1370-WJ)

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Target: NCAPD3
Host: Rabbit
Specificity: Human
Clone: D3H6L
Application*: WB, IP
Datasheet SDS

Mouse Anti-NCAPD3 Recombinant Antibody (1D5) (CBMAB-N1368-WJ)

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Target: NCAPD3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1D5
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-NCAPD3 Recombinant Antibody (CBFYH-2669) (CBMAB-H3717-FY)

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Target: NCAPD3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2669
Application*: WB, P
Datasheet SDS

Mouse Anti-NCAPD3 (Center) Recombinant Antibody (CBFYH-2668) (CBMAB-H3716-FY)

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Target: NCAPD3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2668
Application*: WB, IP
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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