NCF2

NCF2 is neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms.

Neutrophil Cytosolic Factor 2

NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).

Cellular defense response Source: ProtInc
Innate immune response Source: BHF-UCL
Phagocytosis Source: InterPro
Respiratory burst Source: BHF-UCL
Superoxide anion generation Source: UniProtKB
Superoxide metabolic process Source: BHF-UCL

Cytoplasm

Granulomatous disease, chronic, autosomal recessive, 2 (CGD2):
A form of chronic granulomatous disease, a primary immunodeficiency characterized by severe recurrent bacterial and fungal infections, along with manifestations of chronic granulomatous inflammation. It results from an impaired ability of phagocytes to mount a burst of reactive oxygen species in response to pathogens.