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Rabbit Anti-NCF2 Recombinant Antibody (CBWJN-1207) (CBMAB-N1386-WJ)

This product is a Rabbit antibody that recognizes NCF2. The antibody CBWJN-1207 can be used for immunoassay techniques such as: ELISA.
See all NCF2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBWJN-1207
Antibody Isotype
IgG
Application
ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Neutrophil Cytosolic Factor 2
Introduction
This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010]
Entrez Gene ID
4688
UniProt ID
P19878
Alternative Names
Neutrophil Cytosolic Factor 2; NADPH Oxidase Activator 2; Neutrophil Cytosolic Factor 2 (65kD, Chronic Granulomatous Disease, Autosomal 2); Chronic Granulomatous Disease, Autosomal 2; Neutrophil NADPH Oxidase Factor 2; 7 KDa Neutrophil Oxidase Factor;
Function
NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).
Biological Process
Cellular defense response Source: ProtInc
Innate immune response Source: BHF-UCL
Phagocytosis Source: InterPro
Respiratory burst Source: BHF-UCL
Superoxide anion generation Source: UniProtKB
Superoxide metabolic process Source: BHF-UCL
Cellular Location
Cytoplasm
Involvement in disease
Granulomatous disease, chronic, autosomal recessive, 2 (CGD2):
A form of chronic granulomatous disease, a primary immunodeficiency characterized by severe recurrent bacterial and fungal infections, along with manifestations of chronic granulomatous inflammation. It results from an impaired ability of phagocytes to mount a burst of reactive oxygen species in response to pathogens.

Huang, N., Zhang, J., Kuang, S., Li, Z., Zhao, H., Wu, J., ... & Wang, L. (2023). Role of NCF2 as a potential prognostic factor and immune infiltration indicator in hepatocellular carcinoma. Cancer Medicine, 12(7), 8991-9004.

Bakutenko, I. Y., Haurylchyk, I. D., Nikitchenko, N. V., Sechko, E. V., Kozyro, I. A., Tchitchko, A. M., ... & Ryabokon, N. I. (2022). Neutrophil cytosolic factor 2 (NCF2) gene polymorphism is associated with juvenile‐onset systemic lupus erythematosus, but probably not with other autoimmune rheumatic diseases in children. Molecular Genetics & Genomic Medicine, 10(1), e1859.

Azarova, I. E., Klyosova, E. Y., Kolomoets, I. I., & Polonikov, A. V. (2022). Polymorphic Variants of the Neutrophil Cytosolic Factor 2 Gene: Associations with Susceptibility to Type 2 Diabetes Mellitus and Cardiovascular Autonomic Neuropathy. Russian Journal of Genetics, 58(5), 593-602.

Roth, I. L., Salamon, P., Freund, T., Gadot, Y. B. D., Baron, S., Hershkovitz, T., ... & Hagin, D. (2020). Novel NCF2 mutation causing chronic granulomatous disease. Journal of Clinical Immunology, 40, 977-986.

Qin, K., Zheng, Z., He, Y., Gao, Y., Shi, H., Mo, S., ... & Rong, J. (2020). High expression of neutrophil cytosolic factor 2 (NCF2) is associated with aggressive features and poor prognosis of esophageal squamous cell carcinoma. International journal of clinical and experimental pathology, 13(12), 3033.

AlKhater, S. A., Deswarte, C., Casanova, J. L., & Bustamante, J. (2020). A novel variant in the neutrophil cytosolic factor 2 (NCF2) gene results in severe disseminated BCG infectious disease: A clinical report and literature review. Molecular genetics & genomic medicine, 8(6), e1237.

Wang, D., Liu, J., Chen, Q., Yang, R., & Jiang, Q. (2020). Upregulation of glutaminase 2 and neutrophil cytosolic factor 2 is associated with the poor prognosis of glioblastoma. Biomarkers in Medicine, 14(16), 1585-1597.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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