NDOR1

This gene encodes an NADPH-dependent diflavin reductase that contains both flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) binding domains. The encoded protein catalyzes the transfer of electrons from NADPH through FAD and FMN cofactors to potential redox partners. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
Full Name
NADPH Dependent Diflavin Oxidoreductase 1
Function
NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery (PubMed:10625700, PubMed:28648056, PubMed:23596212, PubMed:20802492, PubMed:15900210).

Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of CIAPIN1, another key component of the CIA machinery (PubMed:28648056, PubMed:23596212, PubMed:20802492).

In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins (PubMed:23596212, PubMed:20802492).

It can also reduce the [2Fe-2S] cluster of CISD1 and activate this protein implicated in Fe/S cluster repair (PubMed:28648056).

In vitro can fully activate methionine synthase/MTR in the presence of soluble cytochrome b5/CYB5A (PubMed:12871938).
Biological Process
Cell death Source: UniProtKB
Cellular response to menadione Source: UniProtKB
Electron transport chain Source: UniProtKB
Iron-sulfur cluster assembly Source: ARUK-UCL
Cellular Location
Other locations
perinuclear region
Note: Concentrated in perinuclear structure.
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Anti-NDOR1 antibodies

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Mouse Anti-NDOR1 Recombinant Antibody (5A7) (CBMAB-N1563-WJ)

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Target: NDOR1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 5A7
Application*: E, WB
Datasheet SDS

Mouse Anti-NDOR1 Recombinant Antibody (2G4) (CBMAB-N1562-WJ)

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Target: NDOR1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2G4
Application*: WB, IH, IF
Datasheet SDS

Mouse Anti-NDOR1 Recombinant Antibody (1E3) (CBMAB-N1561-WJ)

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Target: NDOR1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Dog, Mouse
Clone: 1E3
Application*: WB, IH, IF
Datasheet SDS

Mouse Anti-NDOR1 Recombinant Antibody (3A11) (CBMAB-N0208-WJ)

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Target: NDOR1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: 3A11
Application*: E, WB
Datasheet SDS

NDOR1 Matched Antibody Pair (781) (APMAB-781LY)

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Target: NDOR1
Specificity: Human
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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