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Mouse Anti-NDOR1 Recombinant Antibody (3A11) (CBMAB-N0208-WJ)

This product is a Mouse antibody that recognizes NDOR1. The antibody 3A11 can be used for immunoassay techniques such as: ELISA, WB.
See all NDOR1 antibodies
Published Data
Fig.1 Comparison between diflavin oxidoreductase expression profiles and anoxicspecific metabolism of PR-104A in a human cancer cell line panel.
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Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
3A11
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human, Mouse
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
NADPH Dependent Diflavin Oxidoreductase 1
Introduction
This gene encodes an NADPH-dependent diflavin reductase that contains both flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) binding domains. The encoded protein catalyzes the transfer of electrons from NADPH through FAD and FMN cofactors to potential redox partners. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
Entrez Gene ID
Human27158
Mouse78797
UniProt ID
HumanQ9UHB4
MouseA2AI05
Alternative Names
NADPH Dependent Diflavin Oxidoreductase 1; NADPH-Dependent FMN And FAD-Containing Oxidoreductase; NR1; NADPH Dependent FMN And FAD Containing Oxidoreductase; NADPH-Dependent Diflavin Oxidoreductase 1; Novel Reductase 1; EC 1.18.1.-; BA350O14.9;
Function
NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery (PubMed:10625700, PubMed:28648056, PubMed:23596212, PubMed:20802492, PubMed:15900210).

Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of CIAPIN1, another key component of the CIA machinery (PubMed:28648056, PubMed:23596212, PubMed:20802492).

In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins (PubMed:23596212, PubMed:20802492).

It can also reduce the [2Fe-2S] cluster of CISD1 and activate this protein implicated in Fe/S cluster repair (PubMed:28648056).

In vitro can fully activate methionine synthase/MTR in the presence of soluble cytochrome b5/CYB5A (PubMed:12871938).
Biological Process
Cell death Source: UniProtKB
Cellular response to menadione Source: UniProtKB
Electron transport chain Source: UniProtKB
Iron-sulfur cluster assembly Source: ARUK-UCL
Cellular Location
Other locations
perinuclear region
Note: Concentrated in perinuclear structure.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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