Mouse Anti-NDOR1 Recombinant Antibody (2G4) (CBMAB-N1562-WJ)

Name: Mouse Anti-NDOR1 Recombinant Antibody (2G4)
SKU: CBMAB-N1562-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

2G4

Application

WB, IHC, IF

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, 1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

NADPH Dependent Diflavin Oxidoreductase 1

Introduction

This gene encodes an NADPH-dependent diflavin reductase that contains both flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) binding domains. The encoded protein catalyzes the transfer of electrons from NADPH through FAD and FMN cofactors to potential redox partners. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

Entrez Gene ID

27158

UniProt ID

Q9UHB4

Alternative Names

NADPH Dependent Diflavin Oxidoreductase 1; NADPH-Dependent FMN And FAD-Containing Oxidoreductase; NR1; NADPH Dependent FMN And FAD Containing Oxidoreductase; NADPH-Dependent Diflavin Oxidoreductase 1; Novel Reductase 1; EC 1.18.1.-; BA350O14.9;

Function

NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery (PubMed:10625700, PubMed:28648056, PubMed:23596212, PubMed:20802492, PubMed:15900210).

Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of CIAPIN1, another key component of the CIA machinery (PubMed:28648056, PubMed:23596212, PubMed:20802492).

In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins (PubMed:23596212, PubMed:20802492).

It can also reduce the [2Fe-2S] cluster of CISD1 and activate this protein implicated in Fe/S cluster repair (PubMed:28648056).

In vitro can fully activate methionine synthase/MTR in the presence of soluble cytochrome b5/CYB5A (PubMed:12871938).

Biological Process

Cell death Source: UniProtKB
Cellular response to menadione Source: UniProtKB
Electron transport chain Source: UniProtKB
Iron-sulfur cluster assembly Source: ARUK-UCL

Cellular Location

Other locations
perinuclear region
Note: Concentrated in perinuclear structure.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

NDOR1 Matched Antibody Pair (781) (CAT#: APMAB-781LY)

Related Products

Mouse Anti-NDOR1 Recombinant Antibody (5A7) (CAT#: CBMAB-N1563-WJ)

Mouse Anti-NDOR1 Recombinant Antibody (3A11) (CAT#: CBMAB-N0208-WJ)

NDOR1 Matched Antibody Pair (781) (CAT#: APMAB-781LY)

Mouse Anti-NDOR1 Recombinant Antibody (1E3) (CAT#: CBMAB-N1561-WJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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