NEK10

NEK10 (NIMA Related Kinase 10) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AURKA.

Full Name

NIMA Related Kinase 10

Function

Plays a role in the cellular response to UV irradiation. Mediates G2/M cell cycle arrest, MEK autoactivation and ERK1/2-signaling pathway activation in response to UV irradiation. In ciliated cells of airways, it is involved in the regulation of mucociliary transport (PubMed:31959991).

Biological Process

Mucociliary clearance Source: UniProtKB
Positive regulation of MAP kinase activity Source: UniProtKB
Positive regulation of protein autophosphorylation Source: UniProtKB
Protein phosphorylation Source: UniProtKB
Regulation of cell cycle G2/M phase transition Source: UniProtKB
Regulation of ERK1 and ERK2 cascade Source: UniProtKB

Cellular Location

Extracellular region
Other locations
protein kinase complex

Involvement in disease

Ciliary dyskinesia, primary, 44 (CILD44):
A form of primary ciliary dyskinesia, a disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. CILD44 inheritance is autosomal recessive.