Mouse Anti-NEK10 Recombinant Antibody (1C9) (CBMAB-N1916-WJ)

Name: Mouse Anti-NEK10 Recombinant Antibody (1C9)
SKU: CBMAB-N1916-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1C9

Application

ELISA, IF, WB

Specificity

Mouse, Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

NIMA Related Kinase 10

Introduction

NEK10 (NIMA Related Kinase 10) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AURKA.

Entrez Gene ID

Human	152110
Mouse	674895

UniProt ID

Human	Q6ZWH5
Mouse	Q3UGM2

Alternative Names

NIMA Related Kinase 10; NIMA (Never In Mitosis Gene A)- Related Kinase 10; Never In Mitosis A-Related Kinase 10; NimA-Related Protein Kinase 10; EC 2.7.11.1;

Function

Plays a role in the cellular response to UV irradiation. Mediates G2/M cell cycle arrest, MEK autoactivation and ERK1/2-signaling pathway activation in response to UV irradiation. In ciliated cells of airways, it is involved in the regulation of mucociliary transport (PubMed:31959991).

Biological Process

Mucociliary clearance Source: UniProtKB
Positive regulation of MAP kinase activity Source: UniProtKB
Positive regulation of protein autophosphorylation Source: UniProtKB
Protein phosphorylation Source: UniProtKB
Regulation of cell cycle G2/M phase transition Source: UniProtKB
Regulation of ERK1 and ERK2 cascade Source: UniProtKB

Cellular Location

Extracellular region
Other locations
protein kinase complex

Involvement in disease

Ciliary dyskinesia, primary, 44 (CILD44):
A form of primary ciliary dyskinesia, a disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. CILD44 inheritance is autosomal recessive.

Haider, N., Dutt, P., van de Kooij, B., Ho, J., Palomero, L., Pujana, M. A., ... & Stambolic, V. (2020). NEK10 tyrosine phosphorylates p53 and controls its transcriptional activity. Oncogene, 39(30), 5252-5266.

Chivukula, R. R., Montoro, D. T., Leung, H. M., Yang, J., Shamseldin, H. E., Taylor, M. S., ... & Sabatini, D. M. (2020). A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance. Nature medicine, 26(2), 244-251.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

NEK10 Matched Antibody Pair (788) (CAT#: APMAB-788LY)

Related Products

NEK10 Matched Antibody Pair (788) (CAT#: APMAB-788LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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