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Mouse Anti-NEK10 Recombinant Antibody (1C9) (CBMAB-N1916-WJ)

This product is a Mouse antibody that recognizes NEK10. The antibody 1C9 can be used for immunoassay techniques such as: ELISA, IF, WB.
See all NEK10 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Human
Clone
1C9
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, WB

Basic Information

Specificity
Mouse, Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
NIMA Related Kinase 10
Introduction
NEK10 (NIMA Related Kinase 10) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AURKA.
Entrez Gene ID
Human152110
Mouse674895
UniProt ID
HumanQ6ZWH5
MouseQ3UGM2
Alternative Names
NIMA Related Kinase 10; NIMA (Never In Mitosis Gene A)- Related Kinase 10; Never In Mitosis A-Related Kinase 10; NimA-Related Protein Kinase 10; EC 2.7.11.1;
Function
Plays a role in the cellular response to UV irradiation. Mediates G2/M cell cycle arrest, MEK autoactivation and ERK1/2-signaling pathway activation in response to UV irradiation. In ciliated cells of airways, it is involved in the regulation of mucociliary transport (PubMed:31959991).
Biological Process
Mucociliary clearance Source: UniProtKB
Positive regulation of MAP kinase activity Source: UniProtKB
Positive regulation of protein autophosphorylation Source: UniProtKB
Protein phosphorylation Source: UniProtKB
Regulation of cell cycle G2/M phase transition Source: UniProtKB
Regulation of ERK1 and ERK2 cascade Source: UniProtKB
Cellular Location
Extracellular region
Other locations
protein kinase complex
Involvement in disease
Ciliary dyskinesia, primary, 44 (CILD44):
A form of primary ciliary dyskinesia, a disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. CILD44 inheritance is autosomal recessive.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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