Human Recombinant NEK10, Active protein, GST Tag (V2LY-0526-LY5734)

Name: Human Recombinant NEK10, Active protein, GST Tag
SKU: V2LY-0526-LY5734
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant NEK10, Active protein, GST Tag consist of Amino Acid: 266-895 and predicts a molecular mass of 98 kDa.

Molecule Mass

98 kDa

Sequence

Amino Acid: 266-895

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

NIMA Related Kinase 10

Function

Plays a role in the cellular response to UV irradiation. Mediates G2/M cell cycle arrest, MEK autoactivation and ERK1/2-signaling pathway activation in response to UV irradiation. In ciliated cells of airways, it is involved in the regulation of mucociliary transport (PubMed:31959991).

Biological Process

Mucociliary clearance Source: UniProtKB
Positive regulation of MAP kinase activity Source: UniProtKB
Positive regulation of protein autophosphorylation Source: UniProtKB
Protein phosphorylation Source: UniProtKB
Regulation of cell cycle G2/M phase transition Source: UniProtKB
Regulation of ERK1 and ERK2 cascade Source: UniProtKB

Cellular Location

Extracellular region
Other locations
protein kinase complex

Involvement in disease

Ciliary dyskinesia, primary, 44 (CILD44):
A form of primary ciliary dyskinesia, a disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. CILD44 inheritance is autosomal recessive.

Haider, N., Dutt, P., van de Kooij, B., Ho, J., Palomero, L., Pujana, M. A., ... & Stambolic, V. (2020). NEK10 tyrosine phosphorylates p53 and controls its transcriptional activity. Oncogene, 39(30), 5252-5266.

Chivukula, R. R., Montoro, D. T., Leung, H. M., Yang, J., Shamseldin, H. E., Taylor, M. S., ... & Sabatini, D. M. (2020). A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance. Nature medicine, 26(2), 244-251.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

NEK10 Matched Antibody Pair (788) (CAT#: APMAB-788LY)

Antibody Pairs

NEK10 Matched Antibody Pair (788) (CAT#: APMAB-788LY)

Related Products

NEK10 Matched Antibody Pair (788) (CAT#: APMAB-788LY)

Mouse Anti-NEK10 Recombinant Antibody (1C9) (CAT#: CBMAB-N1916-WJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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